Trace Elements in Autopsy Tissues from World Trade Center Decedents

描述（由申请人提供）：本提案的目的是检验以下假设：2001年9月11日之后，来自世界贸易中心（WTC）灰尘、气体或烟雾的微量元素仍存在于人体组织中，因此，可能有助于开发累积WTC暴露的生物标志物。我们的项目将努力实现《扎德罗加法案》的研究目标，即扩大对世界贸易中心灾难对健康影响的了解。使用体内X射线荧光（XRF），我们发现，钛和锑可能已被吸收，并保留在一些世贸组织幸存者的骨骼。我们现在希望通过分析在世界贸易中心健康登记处登记的死亡个体的组织中的微量元素来进一步追求这一假设，这些死亡个体是由纽约首席医学检查官办公室（OCME）尸检的。从2007-2011年进行的WTHBE登记者的大约100个“索引”尸检的组织将可用于研究，沿着从50个匹配的对照尸检的组织。对照尸检将提供正常城市生活中微量元素背景浓度的测量。从入组时的访谈数据将可用于索引尸检，并将揭示WTC微量元素的组织浓度和WTC暴露估计从访谈响应之间的相关性。我们还将比较微量元素的浓度在不同器官的受试者在世界贸易中心的粉尘通过intrichiheal吸入暴露于动物。研究假设的支持将激发更多的研究，以开发指示WTC污染物累积暴露的生物标志物。随着对WTC污染物身体负荷的更好理解，可能会改善WTC幸存者和医疗中观察到的疾病的病因学研究。

DESCRIPTION (provided by applicant): The goal of this proposal is to test the hypothesis that trace elements from World Trade Center (WTC) dust, gas or fumes remain present in human tissues years after 9/11/2001 and, thus, may be useful in developing biomarkers of cumulative WTC exposure. Our project will work towards the research objective of the Zadroga Act of expanding knowledge of the health effects of the World Trade Center disaster. Using in vivo x-ray fluorescence (XRF), we found that Ti and Sb may have been absorbed and retained in the bones of some WTC survivors. We now wish to pursue this hypothesis further by analyzing trace elements in tissues of deceased individuals enrolled in the World Trade Center Health Registry (WTCHR) who were autopsied by the Office of the Chief Medical Examiner (OCME) of the City of New York. Tissues from approximately 100 "index" autopsies of WTCHR registrants conducted in 2007-2011 will be available for study, along with tissues from 50 matched control autopsies. Control autopsies will provide measures of background concentrations of trace elements resulting from normal urban life. Interview data from the time of enrollment will be available for index autopsies and will reveal correlations between tissue concentrations of WTC trace elements and WTC exposure estimated from interview responses. We also will compare concentrations of trace elements in different organs of subjects in the WTCHR with those obtained from animals exposed to WTC dust via intratracheal inhalation. Support of the study hypothesis will inspire additional research to develop biomarkers indicative of cumulative exposures to WTC contaminants. Etiologic studies of diseases observed among WTC survivors and medical treatments might be improved with better understanding of the body burden of WTC contaminants.