Trace Elements in Autopsy Tissues from World Trade Center Decedents

世贸中心死者尸检组织中的微量元素

• 批准号: 8695438
• 负责人: MICHAEL MARMOR
• 金额: $ 45.41万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8695438
• 关键词: Trace; Elements; Autopsy; Tissues; World

DESCRIPTION (provided by applicant): The goal of this proposal is to test the hypothesis that trace elements from World Trade Center (WTC) dust, gas or fumes remain present in human tissues years after 9/11/2001 and, thus, may be useful in developing biomarkers of cumulative WTC exposure. Our project will work towards the research objective of the Zadroga Act of expanding knowledge of the health effects of the World Trade Center disaster. Using in vivo x-ray fluorescence (XRF), we found that Ti and Sb may have been absorbed and retained in the bones of some WTC survivors. We now wish to pursue this hypothesis further by analyzing trace elements in tissues of deceased individuals enrolled in the World Trade Center Health Registry (WTCHR) who were autopsied by the Office of the Chief Medical Examiner (OCME) of the City of New York. Tissues from approximately 100 "index" autopsies of WTCHR registrants conducted in 2007-2011 will be available for study, along with tissues from 50 matched control autopsies. Control autopsies will provide measures of background concentrations of trace elements resulting from normal urban life. Interview data from the time of enrollment will be available for index autopsies and will reveal correlations between tissue concentrations of WTC trace elements and WTC exposure estimated from interview responses. We also will compare concentrations of trace elements in different organs of subjects in the WTCHR with those obtained from animals exposed to WTC dust via intratracheal inhalation. Support of the study hypothesis will inspire additional research to develop biomarkers indicative of cumulative exposures to WTC contaminants. Etiologic studies of diseases observed among WTC survivors and medical treatments might be improved with better understanding of the body burden of WTC contaminants.

描述（由申请人提供）：该提案的目的是检验以下假设：世界贸易中心（WTC）灰尘，气体或烟雾的微量元素仍然存在于2001年9月11日之后的几年中，因此可能有助于开发累积WTC暴露的生物标记物。我们的项目将致力于扩大世界贸易中心灾难健康影响知识的研究目标。使用体内X射线荧光（XRF），我们发现Ti和Sb可能已被吸收并保留在某些WTC幸存者的骨骼中。现在，我们希望通过分析纽约市首席医学检查员办公室（OCME）办公室尸检的死者卫生登记册（WTCHR）的死者组织中的痕量元素进一步提出这一假设。从2007 - 2011年进行的WTCHR注册人的大约100个“指数”尸检的组织以及来自50个匹配的对照尸检的组织。控制尸检将提供由正常城市生活产生的痕量元素的背景浓度的度量​​。从入学时间开始的访谈数据将用于索引尸检，并将揭示WTC微量元素的组织浓度与访谈反应估计的WTC暴露之间的相关性。我们还将比较WTCHR中不同受试者器官中的微量元素与从气管内吸入暴露于WTC粉尘的动物获得的痕量元素。对研究假设的支持将激发更多的研究，以开发出生物标志物，指示对WTC污染物的累积暴露。 WTC幸存者和医学治疗中观察到的疾病的病因学研究可能会得到改善，以更好地了解WTC污染物的身体负担。