Functional Organization of S-Cone In1put to V1

S-Cone 输入到 V1 的功能组织

• 批准号: 6741132
• 负责人: ELIZABETH N JOHNSON
• 金额: $ 4.16万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-12-01 至 2005-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6741132
• 关键词: Scandentia; color visions; computer data analysis; cone cell; electrophysiology; fluorescent dye /probe; imaging /visualization /scanning; neuroanatomy; neurons; postdoctoral investigator; visual cortex; visual stimulus

DESCRIPTION (provided by applicant): Deciphering the spectral coding of neurons provides an important key to understanding the mechanisms of color vision. Although there is a growing body of research on spectral coding in the retina, much less is known about chromatic inputs once they reach central targets. My proposed project focuses on the cortical input of short-wavelength-sensitive cones (scones) by exploring the functional organization and dynamics of s-cone inputs in the primary visual codex (V1) of the tree shrew. In particular, the proposed experiments aim to 1) determine whether stimuli that selectively isolate the s-cones are capable of activating V1 circuits and whether there is a systematic organization of that activity that is different from cortical activation with stimuli that excite the ml-cones, 2) examine the spatial and temporal dynamics of the cortical population response to s-cone mediated signals, 3) compare the laminar distribution of s-cone and ml-cone driven inputs and their degree of convergence onto single V1 neurons. These experiments will explore how activity in the s-cone pathway is represented in V1, providing new insights into the cortical mechanisms that are responsible for color processing.

描述（由申请人提供）：破译神经元的光谱编码提供了理解色觉机制的重要关键。虽然有越来越多的研究机构的光谱编码在视网膜上，更少的是知道的彩色输入，一旦他们到达中央目标。我建议的项目集中在皮层输入的短波长敏感锥（烤饼），通过探索的功能组织和动力学的S-锥输入的主要视觉代码（V1）的树鼩。特别地，所提出的实验旨在1）确定选择性地隔离s-视锥的刺激是否能够激活V1回路，以及是否存在与具有激发m-视锥的刺激的皮层激活不同的该活动的系统组织，2）检查皮层群体对s-视锥介导的信号的响应的空间和时间动态，3）比较s-锥和ml-锥驱动输入的层状分布及其向单个V1神经元的会聚程度。这些实验将探索如何在s-视锥通路的活动是代表在V1，提供新的见解负责颜色处理的皮层机制。