Functional Organization of S-Cone In1put to V1

S-Cone 输入到 V1 的功能组织

• 批准号: 7114329
• 负责人: ELIZABETH N JOHNSON
• 金额: $ 5.04万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7114329
• 关键词: Scandentia; color visions; computer data analysis; cone cell; electrophysiology; fluorescent dye /probe; imaging /visualization /scanning; neuroanatomy; neurons; postdoctoral investigator; visual cortex; visual stimulus

DESCRIPTION (provided by applicant): Deciphering the spectral coding of neurons provides an important key to understanding the mechanisms of color vision. Although there is a growing body of research on spectral coding in the retina, much less is known about chromatic inputs once they reach central targets. My proposed project focuses on the cortical input of short-wavelength-sensitive cones (scones) by exploring the functional organization and dynamics of s-cone inputs in the primary visual codex (V1) of the tree shrew. In particular, the proposed experiments aim to 1) determine whether stimuli that selectively isolate the s-cones are capable of activating V1 circuits and whether there is a systematic organization of that activity that is different from cortical activation with stimuli that excite the ml-cones, 2) examine the spatial and temporal dynamics of the cortical population response to s-cone mediated signals, 3) compare the laminar distribution of s-cone and ml-cone driven inputs and their degree of convergence onto single V1 neurons. These experiments will explore how activity in the s-cone pathway is represented in V1, providing new insights into the cortical mechanisms that are responsible for color processing.

描述（申请人提供）：破译神经元的光谱编码是理解色觉机制的重要关键。尽管对视网膜中光谱编码的研究越来越多，但对到达中心目标后的色光输入知之甚少。我提出的项目重点是通过探索树鼩初级视觉皮层（V1）中s-cone输入的功能组织和动力学来研究短波长的敏感锥体（scone）的皮层输入。特别是，拟议的实验旨在1)确定选择性分离s-cone的刺激是否能够激活V1回路，以及该活动是否有系统的组织，这与刺激ml-cone的皮层激活不同，2)检查皮层群体对s-cone介导信号的时空动态反应。3)比较s-cone和ml-cone驱动输入的层流分布及其在单个V1神经元上的收敛程度。这些实验将探索s锥通路的活动如何在V1中表现出来，为负责颜色处理的皮层机制提供新的见解。