Functional Organization of S-Cone In1put to V1

S-Cone 输入到 V1 的功能组织

• 批准号: 6827372
• 负责人: ELIZABETH N JOHNSON
• 金额: $ 4.83万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6827372
• 关键词: Scandentia; color visions; computer data analysis; cone cell; electrophysiology; fluorescent dye /probe; imaging /visualization /scanning; neuroanatomy; neurons; postdoctoral investigator; visual cortex; visual stimulus

DESCRIPTION (provided by applicant): Deciphering the spectral coding of neurons provides an important key to understanding the mechanisms of color vision. Although there is a growing body of research on spectral coding in the retina, much less is known about chromatic inputs once they reach central targets. My proposed project focuses on the cortical input of short-wavelength-sensitive cones (scones) by exploring the functional organization and dynamics of s-cone inputs in the primary visual codex (V1) of the tree shrew. In particular, the proposed experiments aim to 1) determine whether stimuli that selectively isolate the s-cones are capable of activating V1 circuits and whether there is a systematic organization of that activity that is different from cortical activation with stimuli that excite the ml-cones, 2) examine the spatial and temporal dynamics of the cortical population response to s-cone mediated signals, 3) compare the laminar distribution of s-cone and ml-cone driven inputs and their degree of convergence onto single V1 neurons. These experiments will explore how activity in the s-cone pathway is represented in V1, providing new insights into the cortical mechanisms that are responsible for color processing.

描述(申请人提供)：破译神经元的光谱编码为理解颜色视觉的机制提供了重要的关键。虽然对视网膜光谱编码的研究越来越多，但一旦颜色输入到达中央靶点，人们就知道的要少得多。本研究以短波敏感视锥细胞(Scones)的皮层传入为研究对象，通过研究树鼠初级视觉中枢(V1)中S视锥细胞传入的功能组织和动力学机制。具体地说，这些实验的目的是：1)确定选择性分离S锥体的刺激是否能够激活V1回路，以及这种活动是否存在不同于兴奋ML锥体的皮层刺激的系统性组织；2)研究皮层群体对S锥体介导的信号的反应的时空动力学；3)比较S锥体和ML锥体驱动的传入的层状分布及其在单个V1神经元上的会聚程度。这些实验将探索S视锥通路中的活动如何在V1中呈现，为负责颜色处理的皮质机制提供新的见解。