AUTONOMIC CONTRIBUTION TO ENERGY METABOLISM IN HUMANS

自主对人类能量代谢的贡献

• 批准号: 6684177
• 负责人: KONG Y CHEN
• 金额: $ 10.82万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2005-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6684177
• 关键词: autonomic nervous system; bioenergetics; body physical activity; brain electrical activity; calorimetry; catecholamines; heart rate; human subject; liver cirrhosis; nervous system disorder; patient oriented research; photon absorptiometry

DESCRIPTION (adapted from the application) Energy metabolism plays an important role in body weight control and overall nutrition. Changes in energy expenditure (EE) can alter energy balance. Activity of the autonomic nervous system (ANS) influences daily EE. Previous studies have found associations between resting EE and some measures of ANS activities in certain populations. However, the quantitative roles of ANS activity in regulating other components of EE are unclear. In particular, the ANS regulation of physical activity and associated EE should be investigated since this component contributes the largest variation to daily EE. Some digestive diseases with altered energy metabolism, such as Cirrhosis, also have altered ANS activity, but the relationship between the regulatory mechanisms is unknown. Advances in technology and biomedical engineering can facilitate the accurate measurements of ANS activity, energy metabolism, and physical activity. We will utilize an unique combination of a whole-room indirect calorimetry chamber, a force platform floor, and a electronic activity sensing system to quantify the amount of EE and physical activity in a 24-hour period; multiple portable movement detectors and a novel force measurement insole device that we developed to accurately determine the type, intensity, duration, and frequency of the physical activities in 7 days of free living. We will obtain a comprehensive ANS activity profile includes multiple indices such as plasma catecholamines, urinary excretion of catecholamines, microneurography, and heart rate variability. Using these accurate measurements, we hope to establish quantitative associations between EE and ANS activity. We will explore the role of ANS plays in EE and physical activity in four groups of adult human subjects with various ANS activity levels: 1) a heterogeneous healthy normals, varying in age, gender, weight, and ethnicity, 2) patients with Pure Autonomic Failure who have very low ANS activities, 3) patients with Orthostatic Intolerance who have very high ANS activities, and 4) patients with cirrhosis who have various levels of ANS alterations. Results of this study should lead to improved understanding of ANS in controlling energy metabolism in normal and disease states. Experiences gained from this project and the didactic training will also help me to develop into an independent investigator in biomedical research.

描述（根据应用程序改编） 能量代谢在体重控制和整体体重中起重要作用 营养。能源消耗（EE）的变化可以改变能量平衡。 自主神经系统（ANS）的活性会影响每日EE。以前的 研究发现静止EE与ANS的某些措施之间的关联 某些人群的活动。但是，ANS的定量作用 调节EE其他组件的活性尚不清楚。特别是 应调查对体育活动和相关EE的ANS调节 由于该组件对每日EE造成了最大的变化。一些 能量代谢改变的消化疾病（例如肝硬化）也具有 ANS活动改变了，但是调节机制之间的关系是 未知。 技术和生物医学工程的进步可以促进准确的 ANS活性，能量代谢和体育活动的测量。我们将 利用整个房间间接量热法室的独特组合，一个 力平台地板和电子活动传感系统来量化 在24小时内的EE和体育锻炼量；多个便携式 我们 开发以准确确定类型，强度，持续时间和频率 在7天的自由生活中的体育活动。我们将获得一个 全面的ANS活动概况包括多个索引，例如等离子体 儿茶酚胺，儿茶酚胺的尿液排泄，微功能学和 心率变异性。使用这些准确的测量，我们希望建立 EE与ANS活性之间的定量关联。 我们将探讨ANS扮演在EE和体育活动中的作用。 成人人类受试者的组各种ANS活性水平：1）A 异质健康的正常人，年龄，性别，体重和种族变化， 2）患有非常低的ANS活动的纯自主衰竭患者，3） 具有很高ANS活动的体位不耐受的患者，4） 肝硬化患者患有不同水平的ANS改变。结果 这项研究应提高对控制能量的ANS的理解 正常和疾病状态的代谢。从这个项目中获得的经验 教义培训还将帮助我发展成为一个独立的 生物医学研究研究者。