AUTONOMIC CONTRIBUTIONS TO ENERGY METABOLISM IN HUMANS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。假设：在健康的非肥胖者中，基线自主神经系统(ANS)活动的变化与人体能量消耗(EE)呈正相关，并与体力活动的数量、类型、强度和频率相关。2.)与健康对照组相比，纯自主神经衰竭(PAF)患者的静息EE降低，而立位不耐受(OI)患者的静息EE升高。由于体位变化对血压或心率的调节不佳，两组患者的体力活动量都比正常情况下减少。具体目标：1.)目的：建立健康成人EE各成分与体力活动、ANS活性之间的关系。我们将寻求这些关键问题的答案：a)ANS活动对正常人EE的不同成分有多大影响？b)ANS活动是否影响不同个体进行的体力活动的数量、类型、强度和频率？c)ANS活动测量的哪些标志物是正常健康成年人EE和体力活动的最佳预测因子？目的：确定纯自主神经衰竭和立位不耐受患者与健康正常对照组之间ANS对EE和体力活动的贡献的差异。我们将提出以下问题：a)在这些疾病中，ANS活性、EE和体力活动之间的关系是否呈现出与正常相似的模式？以及b)ANS活动的两个相反频谱的患者在总EE及其成分和底物代谢方面是否存在差异？

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HYPOTHESIS: In healthy non-obese humans, the variation in baseline autonomic nervous system (ANS) activity is positively associated with human energy expenditure (EE, and is correlated wtih the amount, type, intensity, and frequency of the physical activity performed. 2.) Resting EE is lower in Pure Autonomic Failure (PAF) patients and higher in Orthostatic Intolerant (OI) patients than healthy controls. The amount of physical activity in both groups of patients is reduced when compared to normal as a result of poor modulation of blood pressure or heart rate in postural changes. SPECIFIC AIMS: 1.) To establish relationship between the components of EE, physical activity, and ANS activity in healthy normal adults. We will search for answers to these key questions: a) how much does the ANS activity influence different components of EE in normal human adults?, b) does the ANS activity influence the amount, type, intesnity, and frequency of the physical activity performed by different individuals?, and c) which markers of ANS activity measure are the best predictors of EE and physical activity in normal healthy adult humans? 2.) To identify differences in ANS contributions to EE and physical activity between patients with Pure Autonomic Failure and Orthostatic Intolerance and healthy normal controls. We will ask following questions: a) Do the associations between ANS activity, EE, and physical acitivty in these diseases exhibit patterns similar to normal?, and b) are there any differences in total EE and its componenets and substrate metabolism between the patients on the 2 opposite spectrum of ANS activity?