AUTONOMIC CONTRIBUTIONS TO ENERGY METABOLISM IN HUMANS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。假设：在健康的非肥胖人中，基线自主神经系统（ANS）活动的变化与人能量消耗（EE）正相关，并且与所进行的身体活动的量、类型、强度和频率相关。2.）与健康对照组相比，单纯自主神经功能衰竭（PAF）患者的静息EE较低，直立不耐受（OI）患者较高。与正常人相比，两组患者的体力活动量均减少，这是由于姿势变化时血压或心率调节不良。具体目标：1.）建立健康成人EE各组分与体力活动、ANS活性之间的关系。我们将寻找这些关键问题的答案：a）ANS活动对正常成人EE的不同成分有多大影响？B）ANS活动是否影响不同个体进行的身体活动的量、类型、强度和频率？以及c）ANS活动测量的哪些标记物是正常健康成年人中EE和体力活动的最佳预测因子？2.）确定纯自主神经功能衰竭和直立不耐受患者与健康正常对照组之间ANS对EE和体力活动的贡献差异。我们将提出以下问题：a）这些疾病中ANS活动、EE和体力活动之间的关联是否表现出与正常相似的模式？和B）在ANS活性的两个相反谱上的患者之间的总EE及其组分和底物代谢是否有任何差异？

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HYPOTHESIS: In healthy non-obese humans, the variation in baseline autonomic nervous system (ANS) activity is positively associated with human energy expenditure (EE, and is correlated wtih the amount, type, intensity, and frequency of the physical activity performed. 2.) Resting EE is lower in Pure Autonomic Failure (PAF) patients and higher in Orthostatic Intolerant (OI) patients than healthy controls. The amount of physical activity in both groups of patients is reduced when compared to normal as a result of poor modulation of blood pressure or heart rate in postural changes. SPECIFIC AIMS: 1.) To establish relationship between the components of EE, physical activity, and ANS activity in healthy normal adults. We will search for answers to these key questions: a) how much does the ANS activity influence different components of EE in normal human adults?, b) does the ANS activity influence the amount, type, intesnity, and frequency of the physical activity performed by different individuals?, and c) which markers of ANS activity measure are the best predictors of EE and physical activity in normal healthy adult humans? 2.) To identify differences in ANS contributions to EE and physical activity between patients with Pure Autonomic Failure and Orthostatic Intolerance and healthy normal controls. We will ask following questions: a) Do the associations between ANS activity, EE, and physical acitivty in these diseases exhibit patterns similar to normal?, and b) are there any differences in total EE and its componenets and substrate metabolism between the patients on the 2 opposite spectrum of ANS activity?