AUTONOMIC CONTRIBUTION TO ENERGY METABOLISM IN HUMANS

自主对人类能量代谢的贡献

• 批准号: 6254745
• 负责人: KONG Y CHEN
• 金额: $ 10.27万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2005-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6254745
• 关键词: autonomic nervous system; bioenergetics; body physical activity; brain electrical activity; calorimetry; catecholamines; heart rate; human subject; liver cirrhosis; nervous system disorder; patient oriented research; photon absorptiometry

DESCRIPTION (adapted from the application) Energy metabolism plays an important role in body weight control and overall nutrition. Changes in energy expenditure (EE) can alter energy balance. Activity of the autonomic nervous system (ANS) influences daily EE. Previous studies have found associations between resting EE and some measures of ANS activities in certain populations. However, the quantitative roles of ANS activity in regulating other components of EE are unclear. In particular, the ANS regulation of physical activity and associated EE should be investigated since this component contributes the largest variation to daily EE. Some digestive diseases with altered energy metabolism, such as Cirrhosis, also have altered ANS activity, but the relationship between the regulatory mechanisms is unknown. Advances in technology and biomedical engineering can facilitate the accurate measurements of ANS activity, energy metabolism, and physical activity. We will utilize an unique combination of a whole-room indirect calorimetry chamber, a force platform floor, and a electronic activity sensing system to quantify the amount of EE and physical activity in a 24-hour period; multiple portable movement detectors and a novel force measurement insole device that we developed to accurately determine the type, intensity, duration, and frequency of the physical activities in 7 days of free living. We will obtain a comprehensive ANS activity profile includes multiple indices such as plasma catecholamines, urinary excretion of catecholamines, microneurography, and heart rate variability. Using these accurate measurements, we hope to establish quantitative associations between EE and ANS activity. We will explore the role of ANS plays in EE and physical activity in four groups of adult human subjects with various ANS activity levels: 1) a heterogeneous healthy normals, varying in age, gender, weight, and ethnicity, 2) patients with Pure Autonomic Failure who have very low ANS activities, 3) patients with Orthostatic Intolerance who have very high ANS activities, and 4) patients with cirrhosis who have various levels of ANS alterations. Results of this study should lead to improved understanding of ANS in controlling energy metabolism in normal and disease states. Experiences gained from this project and the didactic training will also help me to develop into an independent investigator in biomedical research.

描述（改编自应用程序） 能量代谢在体重控制和总体上起着重要作用 营养能量消耗（EE）的变化可以改变能量平衡。 自主神经系统（ANS）的活动影响日常EE。 研究发现，静息EE和ANS的某些指标之间存在关联， 在某些人群中。然而，ANS的数量作用 调节EE的其他组分的活性尚不清楚。特别是 应调查ANS对体力活动和相关EE的调节 因为这一部分对每日EE的变化贡献最大。 伴有能量代谢改变的消化系统疾病，如肝硬化， ANS活性改变，但调节机制之间的关系是 未知 技术和生物医学工程的进步可以促进准确的 ANS活动、能量代谢和身体活动的测量。我们将 利用一个独特的组合，一个全室间接量热室， 力平台地板，和电子活动传感系统，以量化 24小时内EE和体力活动量;多个便携式 运动检测器和一种新的力测量鞋垫装置， 开发以准确确定类型，强度，持续时间和频率 在自由生活的7天里，我们将获得 全面的ANS活动概况包括血浆等多个指标 儿茶酚胺，尿排泄的儿茶酚胺，微神经造影，和 心率变异性。利用这些精确的测量，我们希望建立 EE和ANS活动之间的定量关联。 我们将探讨ANS在EE和体力活动中的作用， 具有各种ANS活性水平的成年人受试者组：1）a 异质性健康正常人，年龄、性别、体重和种族不同， 2)ANS活动非常低的纯自主神经功能衰竭患者，3） 具有非常高的ANS活性的直立不耐受患者，以及4） 具有不同水平ANS改变的肝硬化患者。结果 这项研究将有助于提高对ANS在控制能量方面的理解。 正常和疾病状态下的代谢。从该项目中获得的经验 教学训练也将帮助我发展成为一个独立的 生物医学研究的调查员。