MENTORED PATIENT-0RIENTED RESEARCH CAREER DEVELOPMENT AW

（改编自申请人摘要）：SCI易患葡萄糖 不耐受和胰岛素抵抗，可能是由于身体的变化 组成和骨骼肌功能障碍，将SCI个体置于 患糖尿病和冠状动脉疾病的风险更大。 在身体健全的人中， 已经报道了葡萄糖耐量的显著改善， 有氧运动，胰岛素敏感性的变化。 电阻 训练也改善了葡萄糖耐量，在更大程度上， 身体健全的人的敏感性。 SCI中的运动反应尚未被 像在普通人群中一样广泛地检查，然而， 人口比健全人口获得的好处要多得多， 改善代谢和功能能力。 提出的假设是， 有氧运动、阻力训练和/或有氧运动的组合 阻力训练可以改善身体成分和葡萄糖耐量， 但只有涉及阻力训练的运动， 在肌肉质量，将显着提高胰岛素敏感性的个人 关于SCI 将招募20名T6-L2运动完全性SCI患者 每年参加以下其中一项运动计划。 科目 将被随机分配到控制或有氧（试验1），阻力（试验 2），和联合（试验3）运动组。 葡萄糖耐量、胰岛素 敏感性和身体脂肪将被确定之前和之后的每一个 练习干预。 如果葡萄糖耐受不良和随后的糖尿病可以预防， SCI患者通过适当的运动量， 可以节省保健费用和提高生活质量。

(Adapted from the applicant's abstract): SCI predispose to glucose intolerance and insulin resistance, presumably due to changes in body composition and skeletal muscle dysfunction, placing SCI individuals at greater risk for diabetes and coronary artery disease. In the able-bodied, marked improvements in glucose tolerance have been reported in response to aerobic exercise, with variable changes in insulin sensitivity. Resistance training has also improved glucose tolerance, and to a greater extent, insulin sensitivity in the able-bodied. Exercise responses in SCI have not been examined as extensively as they have in the general population, and yet this population has significantly more to gain than the able-bodied population by improving metabolic and functional abilities. The proposed hypothesis is that aerobic exercise, resistance training and/or a combination of aerobic exercise and resistance training will improve body composition and glucose tolerance, but only exercise which involves resistance training, and subsequent increases in muscle mass, will significantly improve insulin sensitivity in individuals with SCI. Twenty individuals with motor complete T6-L2 SCI will be recruited each year to participate in one of the following exercise protocols. Subjects will be randomly assigned to control or aerobic (Trial 1), resistance (Trial 2), and combined (Trial 3) exercise groups. Glucose tolerance, insulin sensitivity and body fat will be determined before and after each of the exercise interventions. If glucose intolerance and subsequently diabetes mellitus can be prevented in individuals with SCI by utilizing appropriately dosed exercise, significant savings in health care dollars and improved quality of life could be realized.