MENTORED PATIENT-0RIENTED RESEARCH CAREER DEVELOPMENT AW

(改编自申请人的摘要)：SCI易患葡萄糖 不耐受和胰岛素抵抗，可能是由于身体的变化 组成和骨骼肌功能障碍，将脊髓损伤患者置于 患糖尿病和冠状动脉疾病的风险更大。在身体健全的人中， 据报道，糖耐量显著改善是由于 有氧运动，胰岛素敏感性有不同的变化。抵抗力 训练还改善了葡萄糖耐量，在更大程度上还改善了胰岛素 身体健全者的敏感度。脊髓损伤的运动反应还没有得到 在普通人群中进行了广泛的检查，但这 与健全的人口相比，人口增长的幅度要大得多 提高新陈代谢和机能能力。提出的假设是 有氧运动、耐力训练和/或有氧运动的组合 抵抗力训练将改善身体成分和葡萄糖耐量， 但只有包括抵抗训练和随后增加的训练的运动 在肌肉质量方面，将显著改善个体的胰岛素敏感性 和SCI一起。将招募20名运动完全性T6-L2脊髓损伤患者 每年参加下列锻炼方案之一。科目 将随机分配到对照或需氧(试验1)、耐药(试验1) 2)和联合(试验3)运动组。糖耐量、胰岛素 敏感度和体脂将在每次检查之前和之后进行测定 运动干预。 如果糖耐量异常和随后的糖尿病可以在 脊髓损伤患者利用适当剂量的运动，意义重大 可以节省医疗保健费用，提高生活质量。

(Adapted from the applicant's abstract): SCI predispose to glucose intolerance and insulin resistance, presumably due to changes in body composition and skeletal muscle dysfunction, placing SCI individuals at greater risk for diabetes and coronary artery disease. In the able-bodied, marked improvements in glucose tolerance have been reported in response to aerobic exercise, with variable changes in insulin sensitivity. Resistance training has also improved glucose tolerance, and to a greater extent, insulin sensitivity in the able-bodied. Exercise responses in SCI have not been examined as extensively as they have in the general population, and yet this population has significantly more to gain than the able-bodied population by improving metabolic and functional abilities. The proposed hypothesis is that aerobic exercise, resistance training and/or a combination of aerobic exercise and resistance training will improve body composition and glucose tolerance, but only exercise which involves resistance training, and subsequent increases in muscle mass, will significantly improve insulin sensitivity in individuals with SCI. Twenty individuals with motor complete T6-L2 SCI will be recruited each year to participate in one of the following exercise protocols. Subjects will be randomly assigned to control or aerobic (Trial 1), resistance (Trial 2), and combined (Trial 3) exercise groups. Glucose tolerance, insulin sensitivity and body fat will be determined before and after each of the exercise interventions. If glucose intolerance and subsequently diabetes mellitus can be prevented in individuals with SCI by utilizing appropriately dosed exercise, significant savings in health care dollars and improved quality of life could be realized.