Spinal Cord Injury Exercise and Nutrition Conceptual Engagement (SCIENCE)
脊髓损伤运动和营养概念参与(科学)
基本信息
- 批准号:9290072
- 负责人:
- 金额:$ 48.95万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-01 至 2021-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdipose tissueAdultAdverse effectsAnabolismAtrophicBaltimoreBasal metabolic rateBladder DysfunctionBody CompositionBody WeightBody fatBone DensityC-reactive proteinCardiovascular systemCholesterolCoronary ArteriosclerosisDangerousnessDataDiabetes MellitusDietDiet MonitoringDietary InterventionDyslipidemiasEffectivenessElectric StimulationEnergy MetabolismEquipmentErgometryExerciseFatty acid glycerol estersFunctional disorderFutureGastroparesisGlucoseGlucose IntoleranceHealthHealth BenefitHealth Care CostsHeart DiseasesHome environmentHormonesHypertensionImpaired wound healingImpairmentIndividualInsulin ResistanceInterventionIntervention TrialIntestinesInvestigationKidney DiseasesLegLipidsLiteratureLower ExtremityLungMetabolicMetabolic syndromeMethodsMonitorMotorMuscleMuscle FibersMyocardialObesityOutcome MeasureOverweightParaplegiaPeripheralPersonsPlasmaPolyneuropathyPopulationProtocols documentationPsychosocial FactorQuadriplegiaQuality of lifeRandomizedRecruitment ActivityResearchResearch PersonnelRiskSkinSocietiesSpasticSpinal cord injuryStomachSympathetic Nervous SystemTherapeuticThinnessTimeTissuesTravelUnited StatesUpper ExtremityVisual impairmentVulnerable PopulationsWheelchairsWorkbasecell motilitycomparative efficacycytokinediabetes riskdiabeticdiet and exerciseenergy balanceexercise interventionfitnessglucose metabolismhigh riskimprovedinsulin sensitivitymuscle formnamed groupnutritionpreventprimary outcomeprospectiveresponsesarcopeniasecondary outcomespasticityvascular inflammation
项目摘要
Project Summary:
Problem: There are an estimated 1.2 million persons in the United States with spinal cord injury (SCI) or
dysfunction and recent literature would imply that more than 2/3 are overweight or obese by BMI standards,
and more than 50% of them are glucose intolerant, with one out of five is frankly diabetic. This special
population already has significant functional deficits including reduced mobility, myocardial atrophy, neurogenic
lung dysfunction, bowel and bladder dysfunction, and a high risk for skin breakdown. The additional deficits of
visual impairment, gastroparesis, renal disease, peripheral polyneuropathy, and impaired wound healing
associated with obesity and diabetes impacts independence to a much greater extent in spinal cord injured
(SCI) than in the able-bodied population. Specific Aims: The specific objectives for the current proposal are
to assess the impact of Home-based functional electrical stimulation leg-cycle exercise HBFES LCE + Diet
versus Diet Alone on (Primary Variables) body composition (%Body Fat, Fat Mass and Fat-Free Mass), insulin
sensitivity(SI), glucose effectiveness (SG), and Basal Metabolic Rate (BMR), as well as (Secondary Variables)
lower extremity bone mineral density (BMD), lipid profiles, and hsCRP in adults with motor complete SCI
between C4-T4. Methods: Forty 18-65 y.o. individuals with C4-T4 motor complete (AIS A&B) spinal cord
injury will be recruited over 48 months to participate in a randomized, baseline-controlled, prospective,
interventional trial to assess the impact of a 16-week telemonitored exercise and/or diet intervention on
selected fitness parameters in adults with SCI. Primary outcome measures will include body composition
assessment, insulin sensitivity, glucose effectiveness and BMR, while secondary outcomes will include BMD,
lipid profiles, and hsCRP determined before and after the 16-week interventions. Subjects will be randomly
assigned to either HBFES LCE plus Diet on an RT300 ergometer (Restorative Therapeutics, Inc., Baltimore,
MD) or Diet Alone intervention as determined by a random number generator. Impact: The potential to
reverse and prevent obesity, diabetes and heart disease in this population has tremendous implications on
quality of life and reduced health care costs. Further, the “side-effects” associated with exercise and diet
intervention, including improved cardiovascular fitness, improved cholesterol profiles, improved functional
mobility, reduced body fat, improved gastric motility, and reduced spasticity will also positively impact the SCI
person's ability to maintain a greater degree of independence and contribute longer to the work force and
society. Home-based telemonitored Exercise and Diet to reduce obesity has tremendous potential, therefore,
to improve health and quality of life, while reducing health care costs for persons with high paraplegia and
tetraplegia.
项目总结:
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
DAVID R GATER其他文献
DAVID R GATER的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('DAVID R GATER', 18)}}的其他基金
Spinal Cord Injury Exercise and Nutrition Conceptual Engagement (SCIENCE)
脊髓损伤运动和营养概念参与(科学)
- 批准号:
9996746 - 财政年份:2017
- 资助金额:
$ 48.95万 - 项目类别:
EXERCISE TO REDUCE OBESITY IN SPINAL CORD INJURY
通过锻炼减少脊髓损伤引起的肥胖
- 批准号:
8166552 - 财政年份:2009
- 资助金额:
$ 48.95万 - 项目类别:
BODY COMPOSITION ASSESSMENT IN SPINAL CORD INJURY
脊髓损伤的身体成分评估
- 批准号:
8166574 - 财政年份:2009
- 资助金额:
$ 48.95万 - 项目类别:
EXERCISE TO REDUCE OBESITY IN SPINAL CORD INJURY
通过锻炼减少脊髓损伤引起的肥胖
- 批准号:
7950885 - 财政年份:2008
- 资助金额:
$ 48.95万 - 项目类别:
EXERCISE ON INSULIN SENSITIVITY & GLUCOSE EFFECTIVENESS IN SPINAL CORD INJURY
锻炼胰岛素敏感性
- 批准号:
7199848 - 财政年份:2005
- 资助金额:
$ 48.95万 - 项目类别:
MENTORED PATIENT-0RIENTED RESEARCH CAREER DEVELOPMENT AW
指导式以患者为中心的研究职业发展 AW
- 批准号:
6660554 - 财政年份:2000
- 资助金额:
$ 48.95万 - 项目类别:
MENTORED PATIENT-0RIENTED RESEARCH CAREER DEVELOPMENT AW
指导式以患者为中心的研究职业发展 AW
- 批准号:
6192959 - 财政年份:2000
- 资助金额:
$ 48.95万 - 项目类别:
AEROBIC EXERCISE INTERVENTION ON CAD RISK PROFILES IN SPINAL CORD INJURY
有氧运动对脊髓损伤 CAD 风险状况的干预
- 批准号:
6495787 - 财政年份:2000
- 资助金额:
$ 48.95万 - 项目类别:
AEROBIC EXERCISE INTERVENTION ON CAD RISK PROFILES IN SPINAL CORD INJURY
有氧运动对脊髓损伤 CAD 风险状况的干预
- 批准号:
6568647 - 财政年份:2000
- 资助金额:
$ 48.95万 - 项目类别:
MENTORED PATIENT-0RIENTED RESEARCH CAREER DEVELOPMENT AW
指导式以患者为中心的研究职业发展 AW
- 批准号:
6784681 - 财政年份:2000
- 资助金额:
$ 48.95万 - 项目类别:
相似海外基金
Deciphering the role of adipose tissue in common metabolic disease via adipose tissue proteomics
通过脂肪组织蛋白质组学解读脂肪组织在常见代谢疾病中的作用
- 批准号:
MR/Y013891/1 - 财政年份:2024
- 资助金额:
$ 48.95万 - 项目类别:
Research Grant
ESTABLISHING THE ROLE OF ADIPOSE TISSUE INFLAMMATION IN THE REGULATION OF MUSCLE MASS IN OLDER PEOPLE
确定脂肪组织炎症在老年人肌肉质量调节中的作用
- 批准号:
BB/Y006542/1 - 财政年份:2024
- 资助金额:
$ 48.95万 - 项目类别:
Research Grant
Activation of human brown adipose tissue using food ingredients that enhance the bioavailability of nitric oxide
使用增强一氧化氮生物利用度的食品成分激活人体棕色脂肪组织
- 批准号:
23H03323 - 财政年份:2023
- 资助金额:
$ 48.95万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of new lung regeneration therapies by elucidating the lung regeneration mechanism of adipose tissue-derived stem cells
通过阐明脂肪组织干细胞的肺再生机制开发新的肺再生疗法
- 批准号:
23K08293 - 财政年份:2023
- 资助金额:
$ 48.95万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Canadian Alliance of Healthy Hearts and Minds: Dissecting the Pathways Linking Ectopic Adipose Tissue to Cognitive Dysfunction
加拿大健康心灵联盟:剖析异位脂肪组织与认知功能障碍之间的联系途径
- 批准号:
479570 - 财政年份:2023
- 资助金额:
$ 48.95万 - 项目类别:
Operating Grants
Determinants of Longitudinal Progression of Adipose Tissue Inflammation in Individuals at High-Risk for Type 2 Diabetes: Novel Insights from Metabolomic Profiling
2 型糖尿病高危个体脂肪组织炎症纵向进展的决定因素:代谢组学分析的新见解
- 批准号:
488898 - 财政年份:2023
- 资助金额:
$ 48.95万 - 项目类别:
Operating Grants
A study on the role of brown adipose tissue in the development and maintenance of skeletal muscles
棕色脂肪组织在骨骼肌发育和维持中作用的研究
- 批准号:
23K19922 - 财政年份:2023
- 资助金额:
$ 48.95万 - 项目类别:
Grant-in-Aid for Research Activity Start-up
A mechanism of lipid accumulation in brown adipose tissue
棕色脂肪组织中脂质积累的机制
- 批准号:
10605981 - 财政年份:2023
- 资助金额:
$ 48.95万 - 项目类别:
Obesity and Childhood Asthma: The Role of Adipose Tissue
肥胖和儿童哮喘:脂肪组织的作用
- 批准号:
10813753 - 财政年份:2023
- 资助金额:
$ 48.95万 - 项目类别:
Estrogen Signaling in the Ventromedial Hypothalamus Modulates Adipose Tissue Metabolic Adaptation
下丘脑腹内侧区的雌激素信号调节脂肪组织代谢适应
- 批准号:
10604611 - 财政年份:2023
- 资助金额:
$ 48.95万 - 项目类别: