EXERCISE TO REDUCE OBESITY IN SPINAL CORD INJURY

通过锻炼减少脊髓损伤引起的肥胖

• 批准号: 8166552
• 负责人: DAVID R GATER
• 金额: $ 0.26万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166552
• 关键词: Adult; Blood flow; Bone Density; Cardiac Output; Computer Retrieval of Information on Scientific Projects Database; Electric Stimulation; Energy Metabolism; Ergometry; Exercise; Exercise Tolerance; Funding; Grant; Institution; Left; Leg; Lipids; Lower Extremity; Obesity; Paraplegia; Research; Research Personnel; Resources; Source; Spinal cord injury; United States National Institutes of Health; Upper Extremity; Venous; Ventricular End-Diastolic Volumes; arm; improved; insulin sensitivity; muscle form

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. It is our hypothesis that both Functional Electrical Stimulation Leg Cycle Ergometry (FES LCE) exercise and voluntary Arm Crank Ergometry (ACE) upper extremity exercise will increase whole body energy expenditure, thereby increasing muscle mass, insulin sensitivity, bone mineral density and improving lipid profiles in adults with paraplegia. FES LCE is anticipated to result in greater changes for these e parameters than upper extremity (ACE) exercise because total lower extremity muscle mass is greater and contraction of lower extremity musculature will increase lower extremity venous blood flow, increasing left ventricular end diastolic volume, cardiac output and subsequently exercise tolerance

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们的假设是，功能性电刺激腿部周期测力计（FES LCE）运动和自愿手臂曲柄测力计（ACE）上肢运动都将增加全身能量消耗，从而增加肌肉质量，胰岛素敏感性，骨矿物质密度和改善截瘫成人的血脂谱。 预计FES LCE导致这些e参数的变化大于上肢（ACE）运动，因为下肢总肌肉质量更大，下肢肌肉组织的收缩将增加下肢静脉血流量，增加左心室舒张末期容积、心输出量和随后的运动耐量