MENTORED PATIENT-0RIENTED RESEARCH CAREER DEVELOPMENT AW

指导式以患者为中心的研究职业发展 AW

• 批准号: 6192959
• 负责人: DAVID R GATER
• 金额: $ 12.83万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-29 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6192959
• 关键词: aerobic exercise; body composition; clinical research; clinical trials; coronary disorder; diabetes mellitus; disease /disorder proneness /risk; glucose clamp technique; glucose metabolism; glucose tolerance; hormone regulation /control mechanism; human subject; insulin; insulin sensitivity /resistance; muscle function; noninsulin dependent diabetes mellitus; physical therapy; quality of life; spinal cord injury; striated muscles

(Adapted from the applicant's abstract): SCI predispose to glucose intolerance and insulin resistance, presumably due to changes in body composition and skeletal muscle dysfunction, placing SCI individuals at greater risk for diabetes and coronary artery disease. In the able-bodied, marked improvements in glucose tolerance have been reported in response to aerobic exercise, with variable changes in insulin sensitivity. Resistance training has also improved glucose tolerance, and to a greater extent, insulin sensitivity in the able-bodied. Exercise responses in SCI have not been examined as extensively as they have in the general population, and yet this population has significantly more to gain than the able-bodied population by improving metabolic and functional abilities. The proposed hypothesis is that aerobic exercise, resistance training and/or a combination of aerobic exercise and resistance training will improve body composition and glucose tolerance, but only exercise which involves resistance training, and subsequent increases in muscle mass, will significantly improve insulin sensitivity in individuals with SCI. Twenty individuals with motor complete T6-L2 SCI will be recruited each year to participate in one of the following exercise protocols. Subjects will be randomly assigned to control or aerobic (Trial 1), resistance (Trial 2), and combined (Trial 3) exercise groups. Glucose tolerance, insulin sensitivity and body fat will be determined before and after each of the exercise interventions. If glucose intolerance and subsequently diabetes mellitus can be prevented in individuals with SCI by utilizing appropriately dosed exercise, significant savings in health care dollars and improved quality of life could be realized.

（改编自申请人的摘要）：SCI 易感葡萄糖 不耐受和胰岛素抵抗，可能是由于身体的变化 成分和骨骼肌功能障碍，将 SCI 个体置于 患糖尿病和冠状动脉疾病的风险更大。 在身体健全的情况下， 据报道，葡萄糖耐量显着改善 有氧运动，胰岛素敏感性会发生不同的变化。 反抗 训练还改善了葡萄糖耐量，并在更大程度上改善了胰岛素 身体健全者的敏感性。 SCI 中的运动反应尚未 与在一般人群中进行的广泛检查一样，然而， 人口比健全人口获得的收益要多得多 改善代谢和功能能力。 提出的假设是 有氧运动、阻力训练和/或有氧运动的组合 阻力训练将改善身体成分和葡萄糖耐量， 但仅限于涉及阻力训练和随后的增加的运动 肌肉质量，将显着提高个体的胰岛素敏感性 与SCI。 将招募 20 名运动完整 T6-L2 SCI 患者 每年参加以下一项锻炼方案。 科目 将被随机分配到对照或有氧运动（试验 1）、抵抗运动（试验 2）、联合（试验3）运动组。 葡萄糖耐量、胰岛素 将在每次测试之前和之后确定敏感性和体脂 运动干预。 如果可以预防葡萄糖不耐症和随后的糖尿病 患有 SCI 的人通过适当剂量的运动，可以显着 可以实现医疗保健费用的节省和生活质量的提高。