New Mexico NIEHS Center

新墨西哥州 NIEHS 中心

• 批准号: 6723670
• 负责人: Scott W Burchiel
• 金额: $ 92.45万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6723670
• 关键词: clinical research; environmental exposure; environmental health; environmental toxicology; geographic difference; health disparity; human subject; racial /ethnic difference

The Mission of the New Mexico Environmental Health Sciences Center is to address the needs and concerns of Southwestern communities relating to environmental health issues and to conduct basic and translational research on regionally-relevant environmental public health issues. Many New Mexico and Tribal communities in the Southwest have historically born a disproportionate share of exposure to a wide variety of environmental toxicants in the air, water and soil, and recent evidence raises concerns that members of many communities are suffering adverse health effects from environmental exposures. There has been great interest in recent years in studying genetic susceptibility factors that lead to increased risk of environmental diseases, and indeed many of the studies conducted by our Center investigators look directly at gene and environmental factor interactions. However, there has been little work on the influence of social economic status (SES) and behavioral issues and their influence on environmental disease. There is emerging research that indicates that SES and behavioral issues may play as important a role in disease triggering as genetic factors. The theme of this NIEHS Center will be "Environmental Disease and Health Promotion in Susceptible Southwestern Populations." We will focus on potential environmental causes of airway inflammation, asthma, cancer, and other environmental diseases. This theme was chosen based upon the perceived and real health concerns of our southwestern communities in New Mexico and surrounding areas, as well as the ability of the UNM Health Sciences Center and the Lovelace Respiratory Research Institute (LRRI) to respond to these concerns with population-based studies and translational research projects. The New Mexico NIEHS Center will be led by an Administrative Core, and there will be three Research Cores (RCs), four Facility Cores (FCs), and a Community Outreach and Education Program (COEP). RC1 will focus on gene-environment interactions that are important in environmental disease, RC2 will examine environmental lung diseases including asthma and cancer, and RC3 will be a population health core focusing on public health, behavioral, and issues of SES. This core will also have a component examining Ethical, Social, and Legal Implications (ELSI) for population-based and community-engaged research. The FCs will include FCI: Environmental Assessments and Exposures, FC2: Biotechnology (genomics, proteomics, and innovative flow cytometry), FC3: Biocomputing and Bioinformatics, FC4: Biostatistics (which will also have a geospatial information system, GIS, component). The COEP will focus on established interactions with Native American sovereign nations and communities (Navajo, Zuni, Jemez, Laguna, Acoma, and others) as well as on a community partnership with the Albuquerque South Valley, and with U.S.-Mexico community partners.

新墨西哥州环境健康科学中心的使命是解决西南社区与环境健康问题有关的需求和关切，并就区域相关的环境公共卫生问题进行基础和转化研究。新墨西哥州和西南部的许多部落社区历来都接触过空气、水中的各种环境毒物。 和土壤，最近的证据引起了人们的担忧，即许多社区的成员正因环境暴露而遭受不利的健康影响。近年来，人们对研究导致环境疾病风险增加的遗传易感性因素产生了极大的兴趣，事实上，我们中心研究人员进行的许多研究都直接着眼于基因和环境因素的相互作用。然而，这方面的工作却很少 社会经济地位（SES）和行为问题的影响及其对环境疾病的影响。最新研究表明，社会经济地位和行为问题可能与遗传因素一样在疾病触发中发挥着重要作用。该NIEHS中心的主题是“西南地区易感人群的环境疾病与健康促进”。我们将重点关注气道炎症的潜在环境原因， 哮喘、癌症和其他环境疾病。选择这个主题是基于新墨西哥州西南部社区及周边地区的感知和实际健康问题，以及新墨西哥大学健康科学中心和洛夫莱斯呼吸研究所 (LRRI) 通过基于人群的研究和转化研究项目应对这些问题的能力。新墨西哥州 NIEHS 中心将由 行政核心，将有三个研究核心（RC）、四个设施核心（FC）和一个社区外展和教育计划（COEP）。 RC1将重点关注在环境疾病中重要的基因-环境相互作用，RC2将检查环境性肺部疾病，包括哮喘和癌症，RC3将是人口健康核心，重点关注公共卫生、行为和社会经济地位问题。该核心还将有一个组成部分，审查基于人群和社区参与的研究的道德、社会和法律影响 (ELSI)。 FC 将包括 FCI：环境评估和暴露、FC2：生物技术（基因组学、蛋白质组学和创新流式细胞术）、FC3：生物计算和生物信息学、FC4：生物统计学（还将有地理空间信息系统、GIS 组件）。 COEP 将重点关注与美洲原住民主权国家的既定互动 国家和社区（纳瓦霍族、祖尼族、杰梅斯族、拉古纳族、阿科马族等）以及与阿尔伯克基南谷和美国-墨西哥社区合作伙伴的社区伙伴关系。