New Mexico NIEHS Center

新墨西哥州环境健康科学中心的任务是解决西南社区与环境健康问题有关的需求和关切，并就与区域相关的环境公共健康问题进行基础和翻译研究。历史上，新墨西哥州和西南部的许多部落社区生来就接触到空气、水中的各种环境毒物，比例不成比例 最近的证据引起了人们的关注，即许多社区的成员正遭受环境暴露的不利健康影响。近年来，人们对导致环境疾病风险增加的遗传易感因素的研究非常感兴趣，事实上，我们中心研究人员进行的许多研究直接着眼于基因和环境因素的相互作用。然而，在这方面的工作很少。 社会经济地位和行为问题对环境疾病的影响及其影响。有新的研究表明，SES和行为问题在疾病触发中可能起到与遗传因素同样重要的作用。NIEHS中心的主题是“西南易感人群的环境疾病和健康促进”。我们将重点关注呼吸道炎症的潜在环境原因， 哮喘、癌症和其他环境疾病。选择这一主题是基于新墨西哥州和周边地区西南部社区感知到的和真实的健康问题，以及新墨西哥大学健康科学中心和洛夫莱斯呼吸研究所(LRRI)通过基于人口的研究和转化研究项目回应这些问题的能力。新墨西哥州NIEHS中心将由一名 行政核心，将有三个研究核心(RCS)、四个设施核心(FCS)和一个社区推广和教育方案(COEP)。RC1将专注于环境疾病中重要的基因-环境相互作用，RC2将研究包括哮喘和癌症在内的环境肺部疾病，RC3将成为关注公共健康、行为和SES问题的人口健康核心。该核心还将有一个组成部分，审查以人口为基础的和社区参与的研究的伦理、社会和法律影响(ELSI)。FCS将包括FCI：环境评估和暴露，FC2：生物技术(基因组学、蛋白质组学和创新的流式细胞术)，FC3：生物计算和生物信息学，FC4：生物统计学(还将有一个地理空间信息系统，地理信息系统，组成部分)。COEP将专注于与美洲原住民主权国家建立的互动 它还与国家和社区(纳瓦霍、祖尼、杰梅兹、拉古纳、阿科马等)以及与阿尔伯克基南谷和美国-墨西哥社区合作伙伴建立了社区伙伴关系。

The Mission of the New Mexico Environmental Health Sciences Center is to address the needs and concerns of Southwestern communities relating to environmental health issues and to conduct basic and translational research on regionally-relevant environmental public health issues. Many New Mexico and Tribal communities in the Southwest have historically born a disproportionate share of exposure to a wide variety of environmental toxicants in the air, water and soil, and recent evidence raises concerns that members of many communities are suffering adverse health effects from environmental exposures. There has been great interest in recent years in studying genetic susceptibility factors that lead to increased risk of environmental diseases, and indeed many of the studies conducted by our Center investigators look directly at gene and environmental factor interactions. However, there has been little work on the influence of social economic status (SES) and behavioral issues and their influence on environmental disease. There is emerging research that indicates that SES and behavioral issues may play as important a role in disease triggering as genetic factors. The theme of this NIEHS Center will be "Environmental Disease and Health Promotion in Susceptible Southwestern Populations." We will focus on potential environmental causes of airway inflammation, asthma, cancer, and other environmental diseases. This theme was chosen based upon the perceived and real health concerns of our southwestern communities in New Mexico and surrounding areas, as well as the ability of the UNM Health Sciences Center and the Lovelace Respiratory Research Institute (LRRI) to respond to these concerns with population-based studies and translational research projects. The New Mexico NIEHS Center will be led by an Administrative Core, and there will be three Research Cores (RCs), four Facility Cores (FCs), and a Community Outreach and Education Program (COEP). RC1 will focus on gene-environment interactions that are important in environmental disease, RC2 will examine environmental lung diseases including asthma and cancer, and RC3 will be a population health core focusing on public health, behavioral, and issues of SES. This core will also have a component examining Ethical, Social, and Legal Implications (ELSI) for population-based and community-engaged research. The FCs will include FCI: Environmental Assessments and Exposures, FC2: Biotechnology (genomics, proteomics, and innovative flow cytometry), FC3: Biocomputing and Bioinformatics, FC4: Biostatistics (which will also have a geospatial information system, GIS, component). The COEP will focus on established interactions with Native American sovereign nations and communities (Navajo, Zuni, Jemez, Laguna, Acoma, and others) as well as on a community partnership with the Albuquerque South Valley, and with U.S.-Mexico community partners.