Molecular and Cellular Basis for Digestive Diseases

描述(由申请人提供)： 提交这份申请是为了获得范德比尔特基金会的资金 消化疾病研究中心(VDDRC)。我们的中心？S的主要主题是 消化系统发病机制的分子和细胞机制研究 疾病。VDDRC是多学科的，包括12个不同领域的教职员工 学术部门有45名调查人员(30名正式成员和15名助理 成员)。VDDRC的目标与Vanderbilt的目标一致 大学：1)促进与消化系统疾病相关的研究 综合、协作和多学科的方式；2)加强 VDDRC成员的基础研究能力；3)吸引调查人员不要 参与与消化疾病相关的研究，以追求这些线 调查；4)制定和实施培训和 建立与消化疾病相关研究的青年研究人员队伍；以及 5)促进基础研究成果向临床领域的转移。 成员的调查兴趣分为四个大的研究领域：1) 生长调节：增殖、分化和凋亡，2) 维持上皮完整性，3)肠神经科学，4)胃肠道 生理学和新陈代谢。VDDRC由四个核心研究实验室组成 支持成员：1)微阵列核心，2)细胞和动物 建模核心，3)细胞成像核心，以及4)生物分析(质量 光谱分析)核心。这些核心实验室被整合到我们的中心以 为从事消化系统疾病相关研究的研究人员提供 最新的技术进步和实验设计方面的帮助。VDDRC 支持试点/可行性方案和青年调查员奖励方案，以 培养新手和经验丰富的研究人员参与研究 通过其管理核心与消化系统疾病有关。此核心也 包含生物统计和浓缩计划，并监督财务 VDDRC的管理和运营。

DESCRIPTION (provided by applicant): This application is being submitted to obtain funding for the Vanderbilt Digestive Disease Research Center (VDDRC). Our Center?s major theme is the study of the molecular and cellular mechanisms responsible for digestive diseases. The VDDRC is multidisciplinary, including faculty in 12 different academic departments with 45 investigators (30 full members and 15 associate members). The aims of the VDDRC are aligned with the goals of Vanderbilt University: 1) to promote digestive diseases-related research in an integrative, collaborative and multidisciplinary manner; 2) to enhance the basic research capabilities of VDDRC Members; 3) to attract investigators not involved in digestive diseases-related research to pursue these lines of investigation; 4) to develop and implement programs for training and establishment of young investigators in digestive disease-related research; and 5) to facilitate the transfer of basic research findings to the clinical area. Investigative interests of the members fall into four broad areas of study: 1) growth regulation: proliferation, differentiation, and apoptosis, 2) maintenance of epithelial integrity, 3) enteric neuroscience, and 4) GI physiology and metabolism. The VDDRC contains four core research laboratories to support the members: 1) the Microarray Core, 2) the Cellular and Animal Modeling Core, 3) the Cell Imaging Core, and 4) the Bioanalytical (Mass Spectrometry) Core. These core laboratories were integrated into our Center to provide investigators working on digestive disease-related research with the latest advancements in technology and aid in experimental design. The VDDRC supports a Pilot/ Feasibility Program and a Young Investigator Award Program to foster participation of beginning and seasoned investigators in research related to digestive diseases through its Administrative Core. This Core also contains Biostatistical and Enrichment Programs and oversees the financial management and operation of the VDDRC.