Core Grant for Vision Research

这个应用程序为核心的甘特图视觉研究代表了我们努力建立一个设施为我们的设计满足共同需要多样化的研究项目通过建立核心设施,将(1)提供重要的共享资源加强我们当前项目的某些方面,(2)使我们能够利用新资源的oi加强我们当前项目的某些方面,(2)使我们能够利用的新技术以扩大现有的研究。虽然斯克里普斯研究所的教师研究项目在细胞生物学、化学、免疫学和分子生物学等领域产生了重大影响，但在视觉科学方面的实力只是相对较新的。事实上，在1993年以前，研究所只有一名NEI资助的研究者。从那时起，部分由于细胞生物系的积极招聘，部分由于已建立的研究项目的自然发展，另外9个nei资助的R01被授予斯克里普斯研究所的研究人员。这在很大程度上是由于人们认识到在实验室中进行的基本观察与视觉系统的相关性。虽然这个核心提案中的一些研究人员的研究项目主要集中在视觉系统上，但其他人从完全不同的领域研究眼睛。来自非视觉科学领域的研究人员对视觉细胞生物学的长期承诺得到了加强，因为最近有3人获得了nei资助项目的竞争性更新。在过去的两年里，这些人的互动频率越来越高。来自邻近的加州大学圣地亚哥分校（UCSD）的四位同事也对直接应用于视觉系统的细胞生物学有共同的兴趣。正如本申请中所描述的，核心设施不仅将服务于已经建立的NEI资助的研究人员，而且还将提供一种资源，可以用来激发Scripps和UCSD的其他非NEI资助的研究人员的兴趣和参与。通过将四名加州大学圣地亚哥分校的教师纳入该提案，它也将促进两个机构在视觉细胞生物学领域的互动，并有望进一步促进各自院系之间的合作。

This application for a Core Gant for Vision Research represents our effort to establish a facility designed to meet the common needs for our diverse research programs by establishing a core facility that would (1) provide important shared resources to strengthen certain aspects of our current programs and (2) enable us to take advantage of very new resources oi strengthen certain aspects of our current programs and (2) enable us to take advantage of very new technologies in order to expand existing research. While the Scripps Research Institute faculty research programs have had a major impact in the fields of cell biology, chemistry, immunology and molecular biology, strength in the visual sciences is only relatively recent. In fact, prior to 1993, there was only one NEI- funded investigator at the Institute. Since that time, in part due to active recruitment on the part of the Department of Cell Biology, and in part due to the natural evolution of established research programs, nine additional NEI-funded R01's have been awarded to The Scripps Research Institute investigators. This is largely the result of individuals recognizing the relevance of fundamental observations, made in their laboratories, to the visual system. While several of the investigators in this core proposal have research programs with a primary focus on the visual system, others approach the eye from entirely different fields. The long-term commitment to vision cell biology by the investigators coming from non- vision science areas is strengthened by the fact that 3 have recently received competitive renewals for their NEI-funded projects. Over the past two years these individuals have been interacting with increasing frequency. Four colleagues from the neighboring University of California, San Diego (UCSD) also have common interests in cell biology with direct application to the visual system. The core facility, as described in this application, would not only serve the ends of already established NEI-funded investigators, but would also provide a resource that could serve to stimulate the interest and participation of other, non- NEI funded, investigators at Scripps and UCSD. By including four UCSD faculty in this proposal, it would also facilitate the interaction between the two institutions in the field of vision cell biology and hopefully lead to further collaborative efforts between the respective faculties.