Core Grant for Vision Research

这份申请视觉研究核心甘特的申请代表着我们努力建立一个旨在满足我们多样化研究计划的共同需求的设施，通过建立一个核心设施，该设施将(1)提供重要的共享资源，以加强我们现有计划的某些方面，(2)使我们能够利用非常新的资源来加强我们现有计划的某些方面，以及(2)使我们能够利用非常新的技术来扩大现有研究。虽然斯克里普斯研究所的教员研究项目在细胞生物学、化学、免疫学和分子生物学领域产生了重大影响，但在视觉科学方面的实力才相对较新。事实上，在1993年之前，研究所只有一名由NEI资助的调查员。自那时以来，部分由于细胞生物系的积极招聘，部分由于既定研究项目的自然演变，由NEI资助的额外九个R01‘S被授予斯克里普斯研究所的研究人员。这在很大程度上是个人认识到在他们的实验室中进行的基本观察与视觉系统的相关性的结果。虽然这个核心提案中的几个研究人员的研究计划主要集中在视觉系统上，但其他人则从完全不同的领域接近眼睛。来自非视觉科学领域的研究人员对视觉细胞生物学的长期承诺得到了加强，因为3人最近获得了NEI资助的项目的竞争性续签。在过去的两年里，这些人的互动越来越频繁。来自邻近的加州大学圣地亚哥分校(UCSD)的四名同事对直接应用于视觉系统的细胞生物学也有共同的兴趣。如本申请书所述，核心设施不仅将服务于已经建立的由国家环境政策研究所资助的调查人员的目的，而且还将提供一种资源，以激发其他非国家环境政策研究所资助的斯克里普斯大学和加州大学可持续发展学院的调查人员的兴趣和参与。通过将四名加州大学圣迭戈分校的教员纳入这项建议，还将促进两所院校在视觉细胞生物学领域的互动，并有望促进各自院系之间的进一步合作。

This application for a Core Gant for Vision Research represents our effort to establish a facility designed to meet the common needs for our diverse research programs by establishing a core facility that would (1) provide important shared resources to strengthen certain aspects of our current programs and (2) enable us to take advantage of very new resources oi strengthen certain aspects of our current programs and (2) enable us to take advantage of very new technologies in order to expand existing research. While the Scripps Research Institute faculty research programs have had a major impact in the fields of cell biology, chemistry, immunology and molecular biology, strength in the visual sciences is only relatively recent. In fact, prior to 1993, there was only one NEI- funded investigator at the Institute. Since that time, in part due to active recruitment on the part of the Department of Cell Biology, and in part due to the natural evolution of established research programs, nine additional NEI-funded R01's have been awarded to The Scripps Research Institute investigators. This is largely the result of individuals recognizing the relevance of fundamental observations, made in their laboratories, to the visual system. While several of the investigators in this core proposal have research programs with a primary focus on the visual system, others approach the eye from entirely different fields. The long-term commitment to vision cell biology by the investigators coming from non- vision science areas is strengthened by the fact that 3 have recently received competitive renewals for their NEI-funded projects. Over the past two years these individuals have been interacting with increasing frequency. Four colleagues from the neighboring University of California, San Diego (UCSD) also have common interests in cell biology with direct application to the visual system. The core facility, as described in this application, would not only serve the ends of already established NEI-funded investigators, but would also provide a resource that could serve to stimulate the interest and participation of other, non- NEI funded, investigators at Scripps and UCSD. By including four UCSD faculty in this proposal, it would also facilitate the interaction between the two institutions in the field of vision cell biology and hopefully lead to further collaborative efforts between the respective faculties.