Medial Pain Inputs to Monkey Anterior Cingulate Cortex
猴子前扣带皮层的内侧疼痛输入
基本信息
- 批准号:6720944
- 负责人:
- 金额:$ 28.12万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2003
- 资助国家:美国
- 起止时间:2003-12-01 至 2008-11-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): Anterior cingulate cortex is the most frequently activated cortex in human pain studies and is comprised of perigenual and midcingulate regions. Nociceptive information passes through the midline and intralaminar thalamic nuclei, however, links between the spinothalamic tract and spinoreticulothalamic system to the midline nuclei has never been made directly to cingulate cortex. A case of irritable bowel syndrome with severe visceral pain shows alleviation of symptoms with psychotherapy and reduced midcingulate and increased anterior insular activity. Two hypotheses guide these studies: Functions of perigenual areas 32, 25, 24a-c and midcingulate areas 32' and 24a'-d are driven by different midline thalamic inputs and these nuclei conduct parallel circuits for nociception and stress. Each animal will receive horseradish peroxidase either in the spinal cord or dorsocaudal medullary reticular nucleus, and three fluorescent dextran amine retrograde tracers in contralateral cingulate and/or insular areas followed by reactions for 4 antibodies. Specific Aim #1 will evaluate the immunoarchitecture of the midline and dorsocaudal medullary nuclei with a neuron-specific antibody and antibodies for neurofilaments and calbindin. #2 will determine the projections of the midline nuclei to perigenual, midcingulate, and insular cortices with multiple fluorescent tracers that have the same uptake, transport, and signal properties. #3 will evaluate the topography of inputs to the midline nuclei with anterograde horseradish peroxidase following cervical spinal cord injections. #4 will assess the topography of inputs to the midline nuclei with horseradish peroxidase in the dorsocaudal medullary nucleus. #5 will evaluate overlap of dopamine-13 hydroxylase in each of the midline nuclei with inputs from spinothalamic and medullary nuclei to determine the overlap of nociceptive and stress circuits in the thalamus. These studies will provide the first evidence for differential projections of the midline thalamus to limbic cortex and the extent of spinothalamic, medullary, and locus coeruleus overlap in the medial thalamus and modulatation of sensory, affective, and motor domains of pain processing in anterior cingulate and insular cortices. The mechanisms of medial pain system processing will be identified and this will help interpret human imaging studies and assist in developing objective cdteria and therapies for treating the psychiatric consequences of chronic pain.
描述(申请人提供):前扣带回皮质是人类疼痛研究中最常被激活的皮质,由生殖器周围和中扣带回区域组成。伤害性信息通过丘脑中线和丘脑板内核传递,然而,脊髓丘脑束和脊网丘脑系统与中线核团之间的联系从未直接到达扣带皮质。一例伴有严重内脏疼痛的肠易激综合征患者经心理治疗后症状减轻,中扣带核减少,前岛叶活动增加。两个假说指导着这些研究:外周区32、25、24a-c和中扣带区32‘和24a’-d的功能是由不同的中线丘脑输入驱动的,这些核团为伤害性感受和应激进行平行回路。每只动物将在脊髓或背尾延髓网状核接受辣根过氧化物酶,并在对侧扣带和/或岛区接受三种荧光葡聚糖胺逆行示踪剂,随后对4种抗体进行反应。具体目标#1将用神经元特异性抗体以及神经细丝和钙结合蛋白抗体来评估延髓中线和背侧延髓核的免疫结构。#2将使用具有相同摄取、运输和信号特性的多个荧光示踪剂来确定中线核到生殖周、中扣带和岛叶皮质的投射。#3将在颈髓注射后用顺行辣根过氧化物酶评估中线核团的输入的地形图。#4将用背尾延髓核中的辣根过氧化物酶评估中线核的输入的地形。#5将评估每个中线核中多巴胺-13羟基酶与来自脊髓丘脑和延髓核的输入的重叠,以确定丘脑中伤害性和应激回路的重叠。这些研究将为丘脑中线到边缘皮质的不同投射、内侧丘脑的脊髓丘脑、延髓和蓝斑的重叠程度以及前扣带回和岛叶皮质的痛觉、情感和运动区的调制提供第一个证据。将确定中间疼痛系统处理的机制,这将有助于解释人类成像研究,并有助于开发治疗慢性疼痛的精神后果的客观标准和治疗方法。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Brent Alan Vogt其他文献
Brent Alan Vogt的其他文献
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{{ truncateString('Brent Alan Vogt', 18)}}的其他基金
Medial Pain Inputs to Monkey Anterior Cingulate Cortex
猴子前扣带皮层的内侧疼痛输入
- 批准号:
6984755 - 财政年份:2003
- 资助金额:
$ 28.12万 - 项目类别:
Medial Pain Inputs to Monkey Anterior Cingulate Cortex
猴子前扣带皮层的内侧疼痛输入
- 批准号:
6830847 - 财政年份:2003
- 资助金额:
$ 28.12万 - 项目类别:
Medial Pain Inputs to Monkey Anterior Cingulate Cortex
猴子前扣带皮层的内侧疼痛输入
- 批准号:
7153550 - 财政年份:2003
- 资助金额:
$ 28.12万 - 项目类别:
Medial Pain Inputs to Monkey Anterior Cingulate Cortex
猴子前扣带皮层的内侧疼痛输入
- 批准号:
7340374 - 财政年份:2003
- 资助金额:
$ 28.12万 - 项目类别:
MULTIFOCAL NEURODEGENERATION IN ALZHEIMER'S DISEASE
阿尔茨海默病的多灶性神经变性
- 批准号:
6082539 - 财政年份:2000
- 资助金额:
$ 28.12万 - 项目类别:
MULTIFOCAL NEURODEGENERATION IN ALZHEIMER'S DISEASE
阿尔茨海默病的多灶性神经变性
- 批准号:
6363935 - 财政年份:2000
- 资助金额:
$ 28.12万 - 项目类别:
MULTIFOCAL NEURODEGENERATION IN ALZHEIMER'S DISEASE
阿尔茨海默病的多灶性神经变性
- 批准号:
6312626 - 财政年份:2000
- 资助金额:
$ 28.12万 - 项目类别:
MULTIFOCAL NEURODEGENERATION IN ALZHEIMER'S DISEASE
阿尔茨海默病的多灶性神经变性
- 批准号:
6531091 - 财政年份:2000
- 资助金额:
$ 28.12万 - 项目类别:
MULTIFOCAL NEURODEGENERATION IN ALZHEIMER'S DISEASE
阿尔茨海默病的多灶性神经变性
- 批准号:
6547439 - 财政年份:2000
- 资助金额:
$ 28.12万 - 项目类别:
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