Towards development of eye-safe multiplex resonance raman device for point-of-care neurodiagnostics

致力于开发用于即时神经诊断的人眼安全多重共振拉曼装置

• 批准号: 2435515
• 金额: --
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2435515
• 关键词: Towards; development; eye; safe; multiplex

Aiming at improving trauma triaging and point-of-care and emergency medicine, this project will focus on exploring and validating the Raman-based detection of TBI-indicative biochemical changes from biofluids, brain tissue cultures and in poartcilarly, the cerebrospinal fluid (CSF), collected immediately after TBI. Since the optic nerve is visible at the back-of-the-eye, as a projection of brain tissue and bathed in CSF, it provides an optically clear window into the brain. Therefore, the crucial knowledge acquired during this project, will lay the platform towards development of a novel eye-safe Raman imaging technique to examine the optic nerve and screen for neurological biomarkers as well as allow monitoring drug-delivery, towards developments of new pharmaceutical interventions. This project will enable crucial development steps towards the long-term approach required to address this urgent clinical need, developing a new generation of PoC technology capable of playing a direct role in TBI detection. The implications of having a rapid, non-invasive, quantitative test for TBI would be particularly useful in settings where rapid decisions have to be made regarding whether or not a patient is safe to return to full activity e.g., contact sports or after exposure to blast injury on the battlefield. Engineering novel device and testing it for detection of TBI-indicative markers from biofluids and tissues as well as for monitoring medical interventions and drug delivery post TBI (through rapid, reliable, non-invasive and safe methods of detecting and quantifying TBI), the project will deliver medical tools for better treatment decisions and improved outcomes subsequent to TBI for greater quality of life and ultimately, improved survival. The idea of using laser spectroscopic techniques to non-invasively detect, quantify and monitor treatment of TBI is highly novel and thus, it is likely that this project will break new ground in fields of diagnostic laser applications, advanced optical set-ups, brain-injury and neuro-rehabilitation. The Raman device could find a wide range of related applications in future e.g., in exploring drug interactions within the eye, either in new medicine development or as part of a treatment.

该项目旨在改善创伤分诊和护理点和急诊医学，重点是探索和验证基于拉曼光谱的TBI指示性生物化学变化的检测，这些生物化学变化来自生物液体、脑组织培养物和在脑外伤后立即收集的脑脊液（CSF）。由于视神经在眼睛后部可见，作为脑组织的投影并浸泡在CSF中，它提供了一个光学清晰的大脑窗口。因此，在该项目期间获得的关键知识将为开发新型眼睛安全的拉曼成像技术奠定平台，以检查视神经和筛选神经生物标志物，并允许监测药物递送，以开发新的药物干预措施。 该项目将为解决这一迫切的临床需求所需的长期方法提供关键的发展步骤，开发能够在TBI检测中发挥直接作用的新一代RFID技术。对TBI进行快速、非侵入性、定量测试的意义在必须快速决定患者是否安全恢复完全活动的环境中特别有用，例如，接触性运动或在战场上暴露于爆炸伤后。工程新设备和测试它检测TBI指示标记物从生物液体和组织以及监测医疗干预和药物输送后TBI（通过快速，可靠，非侵入性和安全的方法检测和量化TBI），该项目将提供医疗工具，更好的治疗决策和改善TBI后的结果，以提高生活质量，并最终提高生存率。使用激光光谱技术来非侵入性地检测、量化和监测TBI治疗的想法是非常新颖的，因此，该项目可能会在诊断激光应用、先进的光学装置、脑损伤和神经康复领域开辟新天地。该拉曼装置在未来可以找到广泛的相关应用，在探索药物在眼睛内的相互作用，无论是在新药开发或作为治疗的一部分。