Screening & Brief Intervention of Problem Drinking Women

筛选

• 批准号: 6825512
• 负责人: GRACE CHANG
• 金额: $ 28.78万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-24 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6825512
• 关键词: alcoholic beverage consumption; alcoholism /alcohol abuse; alcoholism /alcohol abuse prevention; behavior modification; behavior therapy; behavioral /social science research tag; clinical research; clinical trials; comorbidity; craving; diabetes mellitus; fertility; goal oriented behavior; health surveys; human subject; human therapy evaluation; hypertension; interview; longitudinal human study; nursing intervention; outcomes research; psychological stressor; questionnaires; women' s health

DESCRIPTION (provided by applicant): Early identification and intervention among problem-drinking women may avert the more severe, adverse consequences of alcohol abuse and dependence. Among nonpregnant women of childbearing age, the use of alcohol and, in particular, the riskier practices of frequent and binge drinking have not changed since 1995. Moreover, 12% of women 60 years and older regularly drink in excess of recommended amounts, and as a group are underscreened and underdiagnosed, despite being the largest group of health care users in the United States. Screening and intervention, while generally effective, have not been adequately tested among women who account for only 27% of brief intervention trial subjects since 1995, despite the NIH guidelines on inclusion of women in clinical trials. This is concerning, as women in general are more vulnerable to alcohol's negative effects due to differences in metabolism. The purpose of this randomized trial is to test the effectiveness of screening and brief intervention for risk drinking by nonpregnant women with specific medical problems exacerbated by excessive alcohol consumption. The medical problems are female factor infertility, hypertension, and diabetes, conditions that are costly to treat and difficult to manage. 552 nonpregnant women with risk drinking (exceeding NIAAA sensible drinking limits of 7 drinks a week or 1-2 drinks per episode) and infertility, hypertension, or diabetes will be randomized to receive either a nurse practitioner delivered brief intervention using Personal Steps to a Healthy Choice: A Woman's Guide or medical treatment as usual. The specific aim of this randomized clinical trial is to test the hypothesis that 45% of the women who receive the medically oriented brief intervention and 30% of the control group will achieve NIAAA sensible drinking limits in the 12 months after study enrollment. This proposed targeted study of women responds to PA-02-168, which seeks research on screening and interventions in medical settings, and builds upon our previous research on brief interventions for pregnant women.

描述（由申请人提供）：对酗酒问题妇女的早期识别和干预可以避免酒精滥用和依赖的更严重的不良后果。自1995年以来，在未怀孕的育龄妇女中，酒精的使用，特别是频繁和酗酒的危险做法没有改变。此外，60岁及以上的妇女中有12%经常饮酒超过建议量，作为一个群体，尽管她们是美国最大的医疗保健用户群体，但她们的筛查和诊断不足。筛查和干预虽然总体上是有效的，但没有在女性中进行充分的测试，自1995年以来，女性只占短暂干预试验对象的27%，尽管美国国立卫生研究院（NIH）制定了将女性纳入临床试验的指南。这令人担忧，因为由于新陈代谢的差异，女性一般更容易受到酒精的负面影响。本随机试验的目的是测试筛查和短暂干预的有效性，以防止因过量饮酒而加重特定医疗问题的非怀孕妇女的危险饮酒。医疗问题是女性因素导致的不孕不育、高血压和糖尿病，这些疾病治疗费用高昂，难以控制。552名有危险饮酒（超过NIAAA合理饮酒限制每周7杯或每次1-2杯）和不孕症、高血压或糖尿病的非孕妇将被随机分组，接受执业护士提供的简短干预，使用健康选择的个人步骤：女性指南或常规药物治疗。本随机临床试验的具体目的是验证在研究入组后的12个月内，45%接受医学导向的短暂干预的妇女和30%的对照组妇女达到NIAAA合理饮酒限制的假设。这项针对女性的针对性研究回应了PA-02-168，该研究旨在研究医疗环境中的筛查和干预措施，并建立在我们之前对孕妇的简短干预研究的基础上。