Screening & Brief Intervention of Problem Drinking Women

筛选

• 批准号: 7253403
• 负责人: GRACE CHANG
• 金额: $ 32.29万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-24 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7253403
• 关键词: Accounting; Alcohol abuse; Alcohol consumption; Alcohols; Clinical Trials; Condition; Control Groups; Dependence; Diabetes Mellitus; Diagnosis; Diagnostic; Early identification; Effectiveness; Enrollment; Female; Female of child bearing age; Guidelines; Healthcare; Heavy Drinking; Hypertension; Infertility; Intervention; Intervention Trial; Interview; Medical; Metabolism; National Institute on Alcohol Abuse and Alcoholism; Nurse Practitioners; Pregnant Women; Purpose; Randomized; Randomized Clinical Trials; Randomized Controlled Clinical Trials; Research; Risk; Screening procedure; Services; Testing; Thinking; United States; United States National Institutes of Health; Week; Woman; alcohol related problem; binge drinking; drinking; early /brief intervention /therapy; follow-up

DESCRIPTION (provided by applicant): Early identification and intervention among problem-drinking women may avert the more severe, adverse consequences of alcohol abuse and dependence. Among nonpregnant women of childbearing age, the use of alcohol and, in particular, the riskier practices of frequent and binge drinking have not changed since 1995. Moreover, 12% of women 60 years and older regularly drink in excess of recommended amounts, and as a group are underscreened and underdiagnosed, despite being the largest group of health care users in the United States. Screening and intervention, while generally effective, have not been adequately tested among women who account for only 27% of brief intervention trial subjects since 1995, despite the NIH guidelines on inclusion of women in clinical trials. This is concerning, as women in general are more vulnerable to alcohol's negative effects due to differences in metabolism. The purpose of this randomized trial is to test the effectiveness of screening and brief intervention for risk drinking by nonpregnant women with specific medical problems exacerbated by excessive alcohol consumption. The medical problems are female factor infertility, hypertension, and diabetes, conditions that are costly to treat and difficult to manage. 552 nonpregnant women with risk drinking (exceeding NIAAA sensible drinking limits of 7 drinks a week or 1-2 drinks per episode) and infertility, hypertension, or diabetes will be randomized to receive either a nurse practitioner delivered brief intervention using Personal Steps to a Healthy Choice: A Woman's Guide or medical treatment as usual. The specific aim of this randomized clinical trial is to test the hypothesis that 45% of the women who receive the medically oriented brief intervention and 30% of the control group will achieve NIAAA sensible drinking limits in the 12 months after study enrollment. This proposed targeted study of women responds to PA-02-168, which seeks research on screening and interventions in medical settings, and builds upon our previous research on brief interventions for pregnant women.

描述(由申请人提供)：在有问题的饮酒妇女中及早识别和干预可能会避免酒精滥用和依赖带来的更严重的不良后果。自1995年以来，在非怀孕育龄妇女中，饮酒，尤其是风险更高的频繁饮酒和狂饮的做法没有改变。此外，12%的60岁及以上女性饮酒量经常超过推荐量，作为一个群体，尽管是美国最大的医疗保健使用者群体，但仍未得到充分筛查和诊断。筛查和干预虽然普遍有效，但自1995年以来只占短暂干预试验受试者27%的妇女没有得到充分的测试，尽管NIH关于将妇女纳入临床试验的指导方针。这一点令人担忧，因为由于新陈代谢的差异，女性一般更容易受到酒精负面影响的影响。这项随机试验的目的是测试对因过量饮酒而加剧特定健康问题的非怀孕妇女进行风险饮酒筛查和短暂干预的有效性。医学上的问题是女性因素不孕不育、高血压和糖尿病，这些疾病的治疗成本很高，很难管理。552名有饮酒风险(超过NIAAA合理饮酒限制，每周7杯或每集1-2杯)并患有不孕不育、高血压或糖尿病的非怀孕女性将被随机分为两组，一组接受使用《健康选择个人步骤：妇女指南》进行短暂干预的护士从业人员，另一组照常接受医疗治疗。这项随机临床试验的具体目的是检验这样一种假设，即接受医学导向的短暂干预的女性中有45%和对照组的30%将在研究登记后的12个月内达到NIAAA合理的饮酒限制。这项拟议的针对妇女的研究是对PA-02-168的响应，该研究寻求在医疗环境中进行筛查和干预的研究，并建立在我们之前关于孕妇简短干预的研究基础上。