Quantitative Mass Spectrometry

定量质谱分析

• 批准号: 6838395
• 负责人: Kenneth Tomer
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6838395
• 关键词: androgen receptor; arachidonate; cardiovascular disorder; cytochrome P450; gas chromatography mass spectrometry; human morbidity; human mortality; liquid chromatography mass spectrometry; mass spectrometry; oxidative stress; prostate neoplasms

Quantitative Mass Spectrometry incorporates collaborative projects in which the Mass Spectrometry Group provides quantitative information about, typically, small molecules by GC/MS, LC/MS and LC/MS/MS or a combination. An example of the types of projects this includes is the isoprostane analyses undertaken as part of the NIEHS led study of biomarkers of oxidative stress. We currently have two major collaborations underway: 1) with Darryl Zeldin on Atherosclerosis Risk In Communities (ARIC) Ancillary Study, and 2) with James Mohler on Interference with the Androgen Receptor and its Ligands in Recurrent Prostate Cancer.

定量质谱法包括合作项目，其中质谱组通过GC/MS，LC/MS和LC/MS/MS或组合提供有关小分子的定量信息。这包括的项目类型的一个例子是作为NIEHS领导的氧化应激生物标志物研究的一部分进行的异前列烷分析。我们目前正在进行两项主要合作：1）与Darryl Zeldin进行社区动脉粥样硬化风险（ARIC）辅助研究，2）与James Mohler进行复发性前列腺癌中雄激素受体及其配体的干扰。