Potassium Channels and Dendritic Function in Hippocampa*

海马中的钾通道和树突功能*

• 批准号: 6813986
• 负责人: Dax A Hoffman
• 金额: --
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6813986
• 关键词: dendrites; electrophysiology; hippocampus; neural plasticity; neural transmission; potassium channel; synapses; voltage /patch clamp; voltage gated channel

A nonuniform density of subthreshold, rapidly inactivating potassium channels regulates signal propagation in the dendrites of CA1 pyramidal neurons of the hippocampus. This nonuniform distribution (with higher expression in the dendrites than in the soma) means that the electrical properties of the dendrites are markedly different from those of the soma. Incoming synaptic signals are shaped by the activity of these channels, and action potentials, once initiated in the axon, progressively decrease in amplitude as they propagate back into the dendrites. By combining patch clamp recording in brain slices of the hippocampus with molecular biology techniques, the Molecular Neurophysiology and Biophysics Unit investigates the electrophysiological properties and molecular nature of the voltage-gated channels expressed in CA1 dendrites, how their expression is regulated, and their role in synaptic integration and plasticity.

不均匀密度的阈下快速失活钾通道调节海马CA1锥体神经元树突中的信号传播。这种不均匀分布（在树突中的表达高于在索马中的表达）意味着树突的电特性与索马的电特性显着不同。传入的突触信号由这些通道的活动形成，并且一旦在轴突中启动，动作电位的幅度随着它们传播回树突而逐渐减小。通过结合膜片钳记录在海马的脑切片与分子生物学技术，分子神经生理学和生物物理学单位调查的电生理特性和分子性质的电压门控通道表达在CA1树突，它们的表达是如何调节，以及它们在突触整合和可塑性的作用。