PCB Congener/Metabolite Patterns in Akwesasne Mohawks

描述（由申请人提供）：奥尔巴尼大学与阿克韦森的莫霍克民族合作，对阿克韦森的多氯联苯（PCB）污染进行了广泛的调查，并收集了大量莫霍克儿童和成人的暴露、健康和临床数据。本实验室研究的长期目标是确定多氯联苯（PCB）身体负担的个别决定因素，包括与阿克韦森内莫霍克人和其他接触人群中受污染生物群的消费有关的决定因素。身体负荷以组织中存在的单个多氯联苯（PCB）同系物的绝对和相对水平为特征，是多氯联苯（PCB）潜在健康损害的重要预测指标。多种暴露相关和毒性动力学介导的因素可影响多氯联苯（PCB）的身体负担。

DESCRIPTION (provided by applicant): In partnership with the Mohawk Nation at Akwesasne, the University at Albany has conducted extensive investigation of polychlorinated biphenyl (PCB) contamination at Akwesasne and has collected a large amount of exposure, health, and clinical data for Mohawk children and adults. The long-term objective of research in this laboratory is to identify individual determinants of polychlorinated biphenyl (PCB) body burden, including those related to consumption of contaminated biota, in the Akwesasne Mohawks and in other exposed populations. Body burden, which is characterized by the absolute and relative levels of individual polychlorinated biphenyl (PCB) congeners present in tissue, is an important predictor of potential health impairment from polychlorinated biphenyls (PCBs). Multiple exposure-related and toxicokinetics-mediated factors can influence polychlorinated biphenyl (PCB) body burden. This renewal application will expand current work on characterizing polychlorinated biphenyl (PCB) exposure in the Akwesasne Mohawk population by application of multivariate exploratory data analysis and other statistical techniques, with the goal of identifying source-, route-, and toxicokinetics-specific exposure indicators. The presence of five major contributing serum polychlorinated biphenyl (PCB) profiles previously identified in Mohawk adults will be correlated with relevant demographic, exposure, and environmental variables. The study will be expanded to include comparative analyses of polychlorinated biphenyl (PCB) profiles determined in a cohort of Mohawk children and adolescents. To provide data to assess current body burden, time-dependent changes in congener profiles, and elimination kinetics of individual congeners, new blood specimens will be analyzed from 100 adults. Finally, a complementary database of major serum hydroxylated polychlorinated biphenyl (PCB) metabolites in adult Mohawks will be established for comparative statistical analysis. These proposed studies are expected to facilitate ongoing exposure and health effects studies of polychlorinated biphenyls (PCBs) at Akwesasne and are important for understanding the potential health risks from these compounds in general.