PCB Congener/Metabolite Patterns in Akwesasne Mohawks

描述(由申请人提供)：奥尔巴尼大学与Akwesasne的莫霍克民族合作，对Akwesasne的多氯联苯(PCB)污染进行了广泛的调查，并收集了大量莫霍克儿童和成人的暴露、健康和临床数据。该实验室研究的长期目标是确定多氯联苯(PCBe)身体负担的个别决定因素，包括与Akwesasne莫霍克和其他暴露人群中受污染生物群的消费有关的决定因素。人体负荷以组织中存在的单个多氯联苯(PCBs)同系物的绝对和相对水平为特征，是多氯联苯(PCbs)潜在健康损害的重要预测指标。多种暴露相关和毒代动力学中介因素会影响多氯联苯(PCBs)的身体负荷。 这一更新申请将通过应用多变量探索性数据分析和其他统计技术，扩大目前在Akwesasne Mohawk人口中表征多氯联苯(PCBs)暴露的工作，目的是确定来源、路线和毒物动力学特定的暴露指标。以前在莫霍克成人中发现的五种主要的血清多氯联苯(PCBs)图谱的存在将与相关的人口统计、暴露和环境变量相关。这项研究将扩大到包括对在莫霍克儿童和青少年队列中确定的多氯联苯(PCBs)特征的比较分析。为了提供数据来评估当前的身体负荷、同类物质谱随时间的变化以及个体同类物质的消除动力学，将对100名成年人的新血液样本进行分析。最后，将建立成年莫霍克族主要血清羟化多氯联苯(PCBs)代谢物的补充数据库，以进行比较统计分析。这些拟议的研究预计将促进Akwesasne正在进行的多氯联苯(PCbs)暴露和健康影响研究，并对于从总体上了解这些化合物的潜在健康风险很重要。

DESCRIPTION (provided by applicant): In partnership with the Mohawk Nation at Akwesasne, the University at Albany has conducted extensive investigation of polychlorinated biphenyl (PCB) contamination at Akwesasne and has collected a large amount of exposure, health, and clinical data for Mohawk children and adults. The long-term objective of research in this laboratory is to identify individual determinants of polychlorinated biphenyl (PCB) body burden, including those related to consumption of contaminated biota, in the Akwesasne Mohawks and in other exposed populations. Body burden, which is characterized by the absolute and relative levels of individual polychlorinated biphenyl (PCB) congeners present in tissue, is an important predictor of potential health impairment from polychlorinated biphenyls (PCBs). Multiple exposure-related and toxicokinetics-mediated factors can influence polychlorinated biphenyl (PCB) body burden. This renewal application will expand current work on characterizing polychlorinated biphenyl (PCB) exposure in the Akwesasne Mohawk population by application of multivariate exploratory data analysis and other statistical techniques, with the goal of identifying source-, route-, and toxicokinetics-specific exposure indicators. The presence of five major contributing serum polychlorinated biphenyl (PCB) profiles previously identified in Mohawk adults will be correlated with relevant demographic, exposure, and environmental variables. The study will be expanded to include comparative analyses of polychlorinated biphenyl (PCB) profiles determined in a cohort of Mohawk children and adolescents. To provide data to assess current body burden, time-dependent changes in congener profiles, and elimination kinetics of individual congeners, new blood specimens will be analyzed from 100 adults. Finally, a complementary database of major serum hydroxylated polychlorinated biphenyl (PCB) metabolites in adult Mohawks will be established for comparative statistical analysis. These proposed studies are expected to facilitate ongoing exposure and health effects studies of polychlorinated biphenyls (PCBs) at Akwesasne and are important for understanding the potential health risks from these compounds in general.