Ultrasound Tissue Erosion for Cardiac Applications

用于心脏应用的超声组织侵蚀

基本信息

批准号：
7390636
负责人：
Charles Alan Cain
金额：
$ 40.47万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-04-15 至 2010-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7390636
关键词：
Acoustics Birth Blood flow Canis familiaris Cardiac Cardiology Cell Nucleus Clinical Clinical Trials Compatible Complex Condition Congenital Heart Defects Data Databases Depth Development Electronics Environment Feedback Frequencies Future Goals Heart Heart Atrium Heart Diseases Heart Septum Hypoplastic Left Heart Syndrome Image In Situ In Vitro Invasive Left atrial structure Life Lithotripsy Localized Mechanics Methods Microbubbles Modeling Monitor Movement Myocardium Necrosis Neonatal Operative Surgical Procedures Optics Optimum Populations Patients Perforation Phase Physiologic pulse Population Procedures Process Production Pulse taking Rate Reconstructive Surgical Procedures Recording of previous events Research Personnel Scanning Signal Transduction Skin Speed Standards of Weights and Measures System Target Populations Techniques Testing Therapeutic Therapeutic Effect Thinking Time Tissues Transducers Ultrasonic Transducer Ultrasonics Ultrasonography Week Width Work base clinical application design design and construction fascinate follow-up in utero in vivo programs research study soft tissue sound

项目摘要

DESCRIPTION (provided by applicant): The primary goal of this application is to develop a highly controlled noninvasive ultrasound procedure to mechanically subdivide and remove tissue, primarily for cardiac applications. The method being developed can be thought of as analogous to lithotripsy for soft tissues. The Controlled Ultrasound Tissue Erosion (CUTE) process is fundamentally different from most soft tissue therapeutic ultrasound procedures in that tissue must be precisely removed instead of producing thermal necrosis in situ. The underlying mechanisms are different from those producing thermal necrosis and need to be fully elucidated so that the erosion process can be rationally optimized. This is the global aim of the proposal. Preliminary results suggest the following mechanistic hypotheses that form the basis of the experimental work proposed herein. 1. The CUTE process depends on co-operative interaction between an initiated "bubble cloud" and the ultrasound insonation where acoustic parameters can be finely tuned (optimized) for the most efficient use of propagated energy, 2. The initiated bubble cloud must be maintained in an optimal state by appropriate adjustment of acoustic parameters, 3. The past history of exposure can predispose the process for optimal future exposure, 4. Pulsed ultrasound is the most effective way to organize the insonation to optimally maintain this complex set of co-operative phenomena. We propose to study these fascinating interactions of sound and bubble ensembles by, 1. Fully exploring acoustic parameter space seeking optimal parameters to maximize therapeutic effects of the propagated energy; and 2. Observing directly the "bubble clouds" by sophisticated optical and acoustic techniques. If we can fully understand these co-operative processes, we will be ably to more effectively optimize the process for specific clinical application. Controlled Ultrasound Tissue Erosion promises to extend the therapeutic rationale of Lithotripsy to all (or most) soft tissues. The applications extend far beyond cardiology although specific cardiac applications are most promising.

描述（由申请人提供）：本申请的主要目标是开发一种高度控制的非侵入性超声程序，以机械细分并去除组织，主要用于心脏应用。可以认为所开发的方法类似于软组织的岩性疗法。受控的超声组织侵蚀（可爱）过程与大多数软组织治疗性超声手术的根本不同，必须精确去除该组织，而不是原位产生热坏死。基本机制与产生热坏死的机制不同，需要完全阐明，以便可以合理地优化侵蚀过程。这是该提案的全球目标。初步结果表明，以下机械假设构成了本文提出的实验工作的基础。 1。可爱的过程取决于启动的“气泡云”与超声检查之间的合作互动，在这些互动中，可以对声学参数进行细调（优化），以最有效地使用传播能量，2。必须通过适当的曝光量来实现pul of pul of Pulsose pulsose pulsose pulsose pulsose pulsose pulsose pulsep offersp。超声是组织任命以最佳维护这一复杂的合作现象的最有效方法。我们建议通过1。完全探索声音参数空间，以寻求最佳参数，以最大程度地提高传播能量的治疗效应； 2。通过复杂的光学和声学技术直接观察“气泡云”。如果我们能够充分理解这些合作过程，我们将可以更有效地优化特定临床应用过程。受控的超声组织侵蚀有望将碎石疗法的治疗原理扩展到所有（或大多数）软组织。尽管特定的心脏应用是最有希望的，但应用程序远远超出了心脏病。

项目成果

期刊论文数量（14）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Noninvasive creation of an atrial septal defect by histotripsy in a canine model.

DOI：
10.1161/circulationaha.109.889071
发表时间：
2010-02-16
期刊：
Circulation
影响因子：
37.8
作者：
Xu Z;Owens G;Gordon D;Cain C;Ludomirsky A
通讯作者：
Ludomirsky A

Size measurement of tissue debris particles generated from pulsed ultrasound cavitational therapy-histotripsy.

DOI：
10.1016/j.ultrasmedbio.2008.09.002
发表时间：
2009-02
期刊：
ULTRASOUND IN MEDICINE AND BIOLOGY
影响因子：
2.9
作者：
Xu, Zhen;Fan, Zhenzhen;Hall, Timothy L.;Winterroth, Frank;Fowlkes, J. Brian;Cain, Charles A.
通讯作者：
Cain, Charles A.

Therapeutic ultrasound to noninvasively create intracardiac communications in an intact animal model.

DOI：
10.1002/ccd.22787
发表时间：
2011-03-01
期刊：
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
影响因子：
2.3
作者：
Owens, Gabe E.;Miller, Ryan M.;Ensing, Greg;Ives, Kimberly;Gordon, David;Ludomirsky, Achi;Xu, Zhen
通讯作者：
Xu, Zhen

Active focal zone sharpening for high-precision treatment using histotripsy.

DOI：
10.1109/tuffc.2011.1808
发表时间：
2011-02
期刊：
IEEE transactions on ultrasonics, ferroelectrics, and frequency control
影响因子：
0
作者：
Wang TY;Xu Z;Hall T;Fowlkes J;Roberts W;Cain C
通讯作者：
Cain C

Noninvasive thrombolysis using pulsed ultrasound cavitation therapy - histotripsy.

DOI：
10.1016/j.ultrasmedbio.2009.07.001
发表时间：
2009-12
期刊：
ULTRASOUND IN MEDICINE AND BIOLOGY
影响因子：
2.9
作者：
Maxwell, Adam D.;Cain, Charles A.;Duryea, Alexander P.;Yuan, Lingqian;Gurm, Hitinder S.;Xu, Zhen
通讯作者：
Xu, Zhen