Imaging Feedback to Guide Ultrasonic Tissue Fractionation for Cancer Therapy

成像反馈指导超声组织分割用于癌症治疗

• 批准号: 8274879
• 负责人: Charles Alan Cain
• 金额: $ 46.41万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-04 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8274879
• 关键词: Ablation; Abscess; Acoustics; Affect; Aftercare; Anatomy; Animals; Arrhythmia; Benign Prostatic Hypertrophy; Cardiac ablation; Cell Death; Cell Survival; Cells; Chronic; Clinical; Development; Effectiveness; Electron Microscopy; Extinction (Psychology); Feedback; Fractionation; Image; Imaging Techniques; Individual; Kidney; Laboratories; Liquid substance; Liver; Local Therapy; Magnetic Resonance Imaging; Malignant - descriptor; Malignant Neoplasms; Malignant neoplasm of brain; Malignant neoplasm of liver; Malignant neoplasm of lung; Malignant neoplasm of prostate; Mechanics; Metastatic Neoplasm to the Liver; Methods; Metric; Molecular; Organelles; Outcome; Physiologic pulse; Process; Prostate; Renal carcinoma; Research; Resolution; Scanning; Scheme; Structure; Techniques; Technology; Therapeutic procedure; Time; Tissues; Ultrasonics; Ultrasonography; Uterine Fibroids; base; breast fibroadenoma; cancer therapy; capsule; clinical application; malignant breast neoplasm; organ capsule; particle; soft tissue; sound; therapy outcome; thrombolysis

DESCRIPTION (provided by applicant): Histotripsy is the controlled use of ultrasound cavitation to mechanically fractionate tissue volumes noninvasively under image guidance. With an appropriate understanding of the dynamics of bubble cloud initiation and extinction, a precise volume of tissue can be fractionated with very narrow boundaries between normal and affected tissue. Since the fractionation occurs at the tissue, cellular, and molecular levels, the results are easily seen by both ultrasound and MR imaging. Moreover, the degree of fractionation is correlated with survival of cells in the treated volume. As fractionation (or liquefaction) progresses, the amount of backscattered sound decreases as well a cell survival. Eventually, when the tissue is highly fractionated, no recognizable cellular organelles can be observed, even with electron microscopy, and the homogenized tissue looks like a fluid with few remaining ultrasound scattering particles. Since the effects of histotripsy are apparent in standard images both during and after treatment, the opportunity to develop image based feedback schemes correlating image parameters with eventual clinical outcomes is obvious. Unlike many other ablation techniques, the imaging based feedback approaches proposed herein can now be developed on a rational basis since the tissue effects can be easily seen and characterized by histological analysis and chronic animal studies where some clinical "outcome" can be determined. Thus, we will develop methods to predict clinical outcome from image parameters available both during and after treatment. This will provide an answer to the critical question for most noninvasive ablative technologies, i.e., when should the treatment be stopped and what will be the spatial extent of the desired treatment? Development of these image guidance techniques could result in a significant transformation in the effectiveness of ablative therapies in a wide range of clinical applications, e.g., prostate cancer, benign prostatic hyperplasia (BPH), breast cancer, fibroadenomas of the breast, liver cancer and metastases, kidney cancer, uterine fibroids, thrombolysis, cardiac ablations for arrhythmia control, lung and brain cancer (under certain conditions), treatment of infected wounds and abscesses, etc.

项目成果

Dual-beam histotripsy: a low-frequency pump enabling a high-frequency probe for precise lesion formation.

• DOI: 10.1109/tuffc.2014.6722617
• 发表时间: 2014-02
• 期刊: IEEE transactions on ultrasonics, ferroelectrics, and frequency control
• 作者: Lin KW;Duryea AP;Kim Y;Hall TL;Xu Z;Cain CA
• 通讯作者: Cain CA

Imaging feedback of histotripsy treatments using ultrasound shear wave elastography.

使用超声剪切波弹性成像进行组织解剖治疗的成像反馈。

• DOI: 10.1109/tuffc.2012.2307
• 发表时间: 2012
• 期刊: IEEE transactions on ultrasonics, ferroelectrics, and frequency control
• 作者: Wang,Tzu-Yin;Hall,TimothyL;Xu,Zhen;Fowlkes,JBrian;Cain,CharlesA
• 通讯作者: Cain,CharlesA

Targeted Lesion Generation Through the Skull Without Aberration Correction Using Histotripsy.

使用组织解剖学通过头骨生成有针对性的病变，无需像差校正。

• DOI: 10.1109/tuffc.2016.2531504
• 发表时间: 2016
• 期刊: IEEE transactions on ultrasonics, ferroelectrics, and frequency control
• 作者: Sukovich,Jonathan;Xu,Zhen;Kim,Yohan;Cao,Hui;Nguyen,Thai-Son;Pandey,Aditya;Hall,Timothy;Cain,Charles
• 通讯作者: Cain,Charles

In vivo histotripsy brain treatment.

• DOI: 10.3171/2018.4.jns172652
• 发表时间: 2019-10
• 期刊: Journal of neurosurgery
• 影响因子: 4.1
• 作者: Jonathan R. Sukovich;C. Cain;A. Pandey;N. Chaudhary;S. Camelo-Piragua;S. Allen;T. Hall;J. Snell;Zhiyuan Xu;J. Cannata;D. Teofilovic;J. Bertolina;N. Kassell;Zhen Xu

Histotripsy beyond the intrinsic cavitation threshold using very short ultrasound pulses: microtripsy.

• DOI: 10.1109/tuffc.2014.6722611
• 发表时间: 2014-02
• 期刊: IEEE transactions on ultrasonics, ferroelectrics, and frequency control
• 作者: Lin KW;Kim Y;Maxwell AD;Wang TY;Hall TL;Xu Z;Fowlkes JB;Cain CA
• 通讯作者: Cain CA