Impact of Micronutrients on Progression of SIV

微量营养素对 SIV 进展的影响

• 批准号: 6710685
• 负责人: SHERWOOD GORBACH
• 金额: $ 48.32万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 2006-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6710685
• 关键词: AIDS therapy; Macaca mulatta; antiAIDS agent; blood tests; body weight; cachexia; combination therapy; diet therapy; dietary supplements; disease /disorder model; helper T lymphocyte; longitudinal animal study; malnutrition; nonhuman therapy evaluation; nutrition related tag; opportunistic infections; pathologic process; selenium; simian immunodeficiency virus; virus diseases; vitamin B12

DESCRIPTION (provided by applicant): Studies in HIV-infected patients have revealed that serum micronutrient levels are often below normal levels, particularly for vitamins A, B about2, and E, as well as for selenium and zinc. Some studies have correlated low micronutrient levels with more rapid progression of HIV infection. Our initial studies in SIVmac239-infected rhesus monkeys have shown low serum levels of Vitamins B12 and E and selenium. Ongoing studies with a highly supplemented (HS) vitamin/micronutrient intervention in SIV-infected animals show a decrease in the rate of loss of weight and body fat compared to placebo controls. For this competitive renewal, we plan to conduct two phases of investigations: 1) single interventions over 36 months of observation in this SIV- infected model with intramuscular Vitamin B 12 and oral selenium, the two most promising micronutrients in human studies; and 2) Conduct an HS vitamin/micronutrient intervention over 36 months in SIV-infected macaques receiving an antiretroviral regimen of HAART (PMPA, ddI, hydroxyurea), which has been shown to produce undetectable SIV viral loads. Primary end points for both studies are time of death and changes in body weight. Secondary end points are measurements of serum micronutrients; changes in lean body mass (by DEXA, bioelectric impedance [BIA], and somatometric measurements); SIV viral load; CD4 cell count; and development of opportunistic infections. Study 1 will show if a single micronutrient such as B 12 or selenium can produce similar effects on end points as the combined HS preparations. Study 2 will simulate the situation of using HAART in HIV/AIDS patients who may have continued weight loss despite suppression of plasma viral load, in order to see if the HS vitamin/micronutrient intervention can maintain weight and improve nutritional status.

描述（由申请人提供）：针对 HIV 感染者的研究 研究表明血清微量营养素水平通常低于正常水平， 特别是维生素 A、B about2 和 E，以及硒和锌。 一些研究将低微量营养素水平与更快的速度联系起来。 HIV感染的进展。我们对 SIVmac239 感染的恒河猴的初步研究 猴子的血清维生素 B12、E 和硒含量较低。进行中 高补充（HS）维生素/微量营养素干预的研究 感染 SIV 的动物体重和体脂下降率下降 与安慰剂对照相比。对于这次竞争性更新，我们计划进行 调查分为两个阶段：1) 超过 36 个月的单次干预 在这种 SIV 感染模型中肌注维生素 B 12 和 口服硒，人类研究中最有前途的两种微量营养素；和 2) 对 SIV 感染者进行 36 个月的 HS 维生素/微量营养素干预 接受HAART抗逆转录病毒疗法（PMPA、ddI、羟基脲）的猕猴， 已被证明可以产生检测不到的 SIV 病毒载量。初级端 这两项研究的重点是死亡时间和体重变化。中学 终点是血清微量营养素的测量；去脂体重的变化 （通过 DEXA、生物电阻抗 [BIA] 和体测测量）； SIV 病毒载量； CD4细胞计数；和机会性感染的发展。学习 1 将显示单一微量营养素（例如 B 12 或硒）是否可以产生 对终点的影响与联合 HS 制剂相似。研究 2 将 模拟对可能患有艾滋病毒/艾滋病的患者使用HAART的情况 尽管血浆病毒载量受到抑制，但仍持续减轻体重，以便看到 HS维生素/微量营养素干预是否可以维持体重并改善体重 营养状况。

项目成果

The effect of micronutrient supplementation on disease progression and death in simian immunodeficiency virus-infected juvenile male rhesus macaques.

微量营养素补充对感染猿猴免疫缺陷病毒的幼年雄性恒河猴疾病进展和死亡的影响。

• DOI: 10.1086/430951
• 发表时间: 2005
• 期刊: The Journal of infectious diseases.
• 作者: Goldin,BarryR;Li,Wenjun;Mansfield,Keith;Woods,Margo;Wanke,Christine;Freeman,Lisa;Shevitz,Abby;Gualtieri,Lisa;Bussell,Sarah;Gorbach,SherwoodL
• 通讯作者: Gorbach,SherwoodL