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Aerosol Dynamics on Inhalation at High Relative Humidity

高相对湿度下吸入的气溶胶动力学

基本信息

批准号：
2440301
负责人：
金额：
--
依托单位：
University of Bristol
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2020
资助国家：
英国
起止时间：
2020 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2440301
关键词：
Aerosol Dynamics Inhalation Relative Humidity

项目摘要

Respiratory droplets are responsible for transmission of diseases such as COVID-19. The physicochemical dynamics of respiratory droplets are not well understood. The representativeness of surrogates for exhaled aerosol currently used for laboratory studies remains debated. In this study, two complementary instruments are used to measure the microphysical dynamics of respiratory surrogate solutions and the temporal evolution of droplet pH. Results show that within the range of ambient relative humidity values, uncertainty in viral survival is dependent upon the complex phase change behaviour of droplets, which in turn is dependent upon droplet composition. Exhaled aerosol experience a shift in pH, from neutral towards alkaline within a millisecond timescale, which is responsible for the infectivity loss of the virus in the aerosol phase. Future experiments will be carried out under a more realistic CO2-regulated environment to better simulate the gas phase conditions experienced by respiratory droplets thus improving the understanding of airborne disease transmission.

呼吸道飞沫是导致 COVID-19 等疾病传播的原因。呼吸道飞沫的物理化学动力学尚不清楚。目前用于实验室研究的呼出气溶胶替代物的代表性仍然存在争议。在这项研究中，使用两种互补的仪器来测量呼吸替代溶液的微物理动力学和液滴 pH 值的时间演变。结果表明，在环境相对湿度值范围内，病毒存活的不确定性取决于液滴的复杂相变行为，而这又取决于液滴的成分。呼出的气溶胶的 pH 值会在毫秒时间内从中性变为碱性，这是导致气溶胶阶段病毒感染性丧失的原因。未来的实验将在更真实的二氧化碳调节环境下进行，以更好地模拟呼吸道飞沫经历的气相条件，从而增进对空气传播疾病传播的理解。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Mucin Transiently Sustains Coronavirus Infectivity through Heterogenous Changes in Phase Morphology of Evaporating Aerosol.

DOI：
10.3390/v14091856
发表时间：
2022-08-24
期刊：
Viruses
影响因子：
0
作者：
Alexander RW;Tian J;Haddrell AE;Oswin HP;Neal E;Hardy DA;Otero-Fernandez M;Mann JFS;Cogan TA;Finn A;Davidson AD;Hill DJ;Reid JP
通讯作者：
Reid JP

Temporal and geographical variation in low carbon inhaler dispensing in England, 2016 to 2021: an ecological study.