Clinical Research on Drug Abuse

药物滥用的临床研究

• 批准号: 6874472
• 负责人: Eric C. Strain
• 金额: $ 12.54万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6874472
• 关键词: behavior therapy; behavioral /social science research tag; buprenorphine; clinical research; clinical trials; cocaine; combination chemotherapy; counseling; dosage; drug abuse; drug abuse chemotherapy; drug addiction antagonist; drug screening /evaluation; fluoxetine; heroin; human subject; human therapy evaluation; mentoring /mentor; methadone; naloxone; pharmacokinetics; questionnaires; tryptophan

DESCRIPTION: (Provided by Applicant): This is a competitive renewal application for a K02 Independent Scientist Award (ISA) from NIDA. The applicant is Eric Strain, a physician-researcher in the Department of Psychiatry at Johns Hopkins University School of Medicine. Dr. Strain has devoted his career to research on drug abuse and to treatment of substance abusing patients, with his primary interest focused upon the development of opioid and cocaine dependence treatment medications. This work has included residential human laboratory studies as well as outpatient clinical trials. There are six short-term and three long-term career goals addressed through the support provided by this ISA. Short-term career goals are: 1) to determine efficacy, safety, and clinical pharmacology of novel substance abuse treatment medications under inpatient experimental conditions, 2) to study efficacy and safety of medications for the treatment of substance abuse disorders utilizing, outpatient clinical trials, 3) to develop and apply methodologies integrating pharmacotherapies with behavioral therapies in clinical trials of substance abuse treatments, 4) to examine the influence of individual characteristics in the course and outcome of substance abuse treatment, 5) to refine expertise in the development process of new medications for the treatment of substance abuse disorders, and 6) to disseminate research findings. Achieving these short-term goals will contribute to accomplishing the first two long-term goals: to contribute new knowledge about the treatment of substance abuse disorder, and to build recognition as an expert in drug abuse treatment and research issues. The final long-term goal is to serve as a mentor and role model for young physicians interested in pursuing a career in substance abuse research. This application's Research Plan provides illustrative investigations that furnish a mechanism for achieving the career goals. These studies examine the pharmacological effects of opioids in human laboratory studies, and test a pharmacotherapy combined with a behavioral therapy in an outpatient clinical trial treating cocaine dependence. This research will be conducted through the Behavioral Pharmacology Research Unit (BPRU), a component of the Hopkins Department of Psychiatry. Dr. Strain has the strong support of the BPRU, the Department of Psychiatry, and the Hopkins School of Medicine, and this ISA provides a mechanism for ensuring the continuation of his highly productive career in substance abuse research. Thus, this ISA represents a good investment by NIDA.

描述：（申请人提供）： 这是K02独立科学家奖的竞争性续期申请 (ISA)来自NIDA申请人是Eric Strain，一位医学研究员， 约翰霍普金斯大学医学院精神病学系。博士 斯特兰把他的职业生涯奉献给了对药物滥用的研究和对 药物滥用患者，他的主要兴趣集中在 开发阿片类药物和可卡因依赖治疗药物。这项工作 包括住宅人类实验室研究以及门诊 临床试验有六个短期和三个长期职业目标 通过该伊萨提供的支持解决。短期职业目标 目的是：1）确定新的药物的疗效、安全性和临床药理学。 在住院实验条件下的药物滥用治疗药物， 2)研究药物治疗物质的有效性和安全性 滥用障碍利用，门诊临床试验，3）开发和应用 将药物治疗与行为治疗相结合的方法， 药物滥用治疗的临床试验，4）检查 药物滥用过程和结果中的个体特征 治疗，5）完善新药开发过程中的专业知识 治疗药物滥用障碍，以及6）传播研究成果 调查结果。实现这些短期目标将有助于实现 前两个长期目标：提供关于治疗糖尿病的新知识， 药物滥用障碍，并建立作为药物滥用专家的知名度 治疗和研究问题。最终的长期目标是担任导师 和榜样的年轻医生有兴趣追求的职业生涯， 药物滥用研究该应用程序的研究计划提供了 提供实现职业生涯的机制的说明性调查 目标.这些研究检查了阿片类药物在人类中的药理作用， 实验室研究，并测试药物治疗结合行为 在一项治疗可卡因依赖的门诊临床试验中，这 研究将通过行为药理学研究单位进行 （BPRU），霍普金斯精神病学系的一个组成部分。应变博士有 BPRU，精神病学系和霍普金斯的大力支持 医学院，这伊萨提供了一个机制，以确保 继续他在药物滥用研究方面卓有成效的职业生涯。因此，在本发明中， 该伊萨代表了NIDA的一项良好投资。