Clinical Research on Drug Abuse

描述：(申请人提供)： 这是K02独立科学家奖的竞争性续签申请 (ISA)来自NIDA。申请者是埃里克·斯特雷特，他是 约翰霍普金斯大学医学院精神病学系。Dr。 斯特拉特致力于药物滥用的研究和治疗 物质滥用患者，他的主要兴趣集中在 阿片类药物和可卡因依赖治疗药物的开发。这部作品 已包括住宅人体实验室研究以及门诊患者 临床试验。有六个短期目标和三个长期职业目标 已通过此ISA提供的支持解决。短期职业目标 目的：1)确定新诺明的有效性、安全性和临床药理学。 住院实验条件下的药物滥用治疗， 2)研究治疗物质的药物的有效性和安全性 滥用障碍利用，门诊临床试验，3)开发和应用 药物疗法与行为疗法相结合的方法学 药物滥用治疗的临床试验，4)检查 药物滥用过程和结果的个体特征 治疗，5)完善新药开发过程中的专业知识 用于治疗药物滥用障碍，以及6)传播研究 调查结果。实现这些短期目标将有助于实现 前两个长期目标：贡献有关治疗的新知识 药物滥用障碍，并建立作为药物滥用专家的认可 治疗和研究问题。最终的长期目标是成为一名导师 和有兴趣从事职业生涯的年轻医生的榜样 药物滥用研究。此应用程序的研究计划提供 为实现职业生涯提供机制的说明性调查 目标。这些研究考察了阿片类药物对人类的药理作用。 实验室研究，并测试药物疗法与行为疗法相结合 治疗可卡因依赖的门诊临床试验。这 研究将通过行为药理学研究股进行 (BPRU)，霍普金斯精神病学系的一个组成部分。斯特拉特博士有 BPRU、精神病学系和霍普金斯大学的大力支持 医学院，这项ISA提供了一种机制，确保 继续他在药物滥用研究方面卓有成效的职业生涯。因此， 这项ISA代表了NIDA的一项不错的投资。

DESCRIPTION: (Provided by Applicant): This is a competitive renewal application for a K02 Independent Scientist Award (ISA) from NIDA. The applicant is Eric Strain, a physician-researcher in the Department of Psychiatry at Johns Hopkins University School of Medicine. Dr. Strain has devoted his career to research on drug abuse and to treatment of substance abusing patients, with his primary interest focused upon the development of opioid and cocaine dependence treatment medications. This work has included residential human laboratory studies as well as outpatient clinical trials. There are six short-term and three long-term career goals addressed through the support provided by this ISA. Short-term career goals are: 1) to determine efficacy, safety, and clinical pharmacology of novel substance abuse treatment medications under inpatient experimental conditions, 2) to study efficacy and safety of medications for the treatment of substance abuse disorders utilizing, outpatient clinical trials, 3) to develop and apply methodologies integrating pharmacotherapies with behavioral therapies in clinical trials of substance abuse treatments, 4) to examine the influence of individual characteristics in the course and outcome of substance abuse treatment, 5) to refine expertise in the development process of new medications for the treatment of substance abuse disorders, and 6) to disseminate research findings. Achieving these short-term goals will contribute to accomplishing the first two long-term goals: to contribute new knowledge about the treatment of substance abuse disorder, and to build recognition as an expert in drug abuse treatment and research issues. The final long-term goal is to serve as a mentor and role model for young physicians interested in pursuing a career in substance abuse research. This application's Research Plan provides illustrative investigations that furnish a mechanism for achieving the career goals. These studies examine the pharmacological effects of opioids in human laboratory studies, and test a pharmacotherapy combined with a behavioral therapy in an outpatient clinical trial treating cocaine dependence. This research will be conducted through the Behavioral Pharmacology Research Unit (BPRU), a component of the Hopkins Department of Psychiatry. Dr. Strain has the strong support of the BPRU, the Department of Psychiatry, and the Hopkins School of Medicine, and this ISA provides a mechanism for ensuring the continuation of his highly productive career in substance abuse research. Thus, this ISA represents a good investment by NIDA.