Mentoring of Clinical Investigators in Patient Oriented Research

指导临床研究人员进行以患者为导向的研究

• 批准号: 7249107
• 负责人: Eric C. Strain
• 金额: $ 18.33万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7249107
• 关键词: Address; Agonist; Analgesics; Area; Award; Behavior Therapy; Biological Availability; Buprenorphine; Characteristics; Classification; Clinical; Clinical Investigator; Clinical Pharmacology; Clinical Research; Clinical Trials; Cocaine; Cocaine Abuse; Cocaine Dependence; Communities; Comorbidity; Development; Disease; Dose; Drug Addiction; Drug abuse; Environment; Faculty; Fellowship; Funding; Goals; Grant; Human; Intervention; Laboratory Study; Lead; Maintenance; Mentors; Mentorship; Mission; National Institute of Drug Abuse; New Agents; Opiate Addiction; Opioid; Oral; Patients; Personal Satisfaction; Persons; Pharmaceutical Preparations; Pharmacotherapy; Physical Dependence; Physicians; Pilot Projects; Positioning Attribute; Psychiatry; Purpose; Range; Recruitment Activity; Relative (related person); Reporting; Research; Research Personnel; Resources; Role; Safety; Schedule; Scientific Advances and Accomplishments; Series; Substance Use Disorder; Substance abuse problem; Support of Research; Symptoms; Testing; Training; Tramadol; United States; United States Food and Drug Administration; United States National Institutes of Health; Universities; Withdrawal; Woman; Work; addiction; base; career; experience; medical schools; member; men; mu opioid receptors; next generation; patient oriented research; prescription document; prescription procedure

DESCRIPTION (provided by applicant): This is an application for a K24 Mid-career Investigator Award in Patient Oriented Research (POR). The applicant is Eric Strain, a physician-researcher in the Department of Psychiatry at Johns Hopkins University School of Medicine. Dr. Strain has devoted his career to POR, and specifically to issues related to research on drug abuse and to treatment of substance abusing patients. His areas of focus have included the development of medications for the treatment of opioid and cocaine dependence, the testing of medications combined with behavioral treatment interventions, the role of psychiatric symptoms and comorbidity in substance use disorders, the testing of abuse liability of medications, and the special treatment needs of women and men with substance abuse. This application describes the candidate's three immediate career goals (to recruit young physicians/clinical investigators to conduct research fellowships in clinical addictions research, to integrate these clinical investigators into ongoing and new studies of POR conducted at the BPRU by providing direct experience in all aspects of clinical investigation, and to assist and mentor these clinical investigators in the transition from fellow to junior faculty member, encouraging each to continue in a career path of addictions-related research). In addition, three long-term career goals are also described (to develop a group of junior, mid-level, and senior clinician investigators with expertise in conducting addictions-related research to serve as a next generation of investigators in substance abuse research at Johns Hopkins, to maintain current investigative strengths of the BPRU while building new complementary areas of clinical research through collaborative efforts within the research community, and to utilize this investigative team in advancing scientific understanding of addictive disorders and their treatment through coordinated efforts). These goals will be accomplished through currently funded research efforts, and a clinical pharmacology study is succinctly presented to illustrate work currently funded by the candidate. In addition, funds from the present application will be used for pilot studies to be conducted with young clinicians, and the research plan for a study comparing tramadol to buprenorphine for the treatment of opioid withdrawal is presented. This work is highly relevant to the mission of NIH and NIDA. Recruiting and training young clinical investigators in the area of addictions are needed to advance understanding and treatment of these disorders. The applicant is well positioned to recruit young clinical investigators, has experience in successfully mentoring young researchers, and is in a strong research environment with excellent resources for mentoring and providing high quality clinical research experiences.

描述（由申请人提供）：这是一个K24职业中期研究者奖在面向患者的研究（POR）的应用程序。申请人是约翰霍普金斯大学医学院精神病学系的医生兼研究员埃里克·斯特兰。Strain博士致力于POR，特别是与药物滥用研究和药物滥用患者治疗相关的问题。他的重点领域包括阿片类药物和可卡因依赖治疗药物的开发，药物与行为治疗干预相结合的测试，精神症状和合并症在药物使用障碍中的作用，药物滥用倾向的测试，以及药物滥用的女性和男性的特殊治疗需求。这份申请描述了候选人的三个近期职业目标（招募年轻的医生/临床研究人员进行临床成瘾研究的研究奖学金，通过提供临床研究各方面的直接经验，将这些临床研究人员纳入BPRU正在进行的和新的POR研究，并协助和指导这些临床研究人员从研究员过渡到初级教员，鼓励每个人继续从事与成瘾相关的研究）。此外，还描述了三个长期职业目标（培养一批具有成瘾相关研究专业知识的初级、中级和高级临床研究人员，作为约翰霍普金斯药物滥用研究的下一代研究人员，保持BPRU目前的研究优势，同时通过研究界的合作努力建立新的补充临床研究领域，并利用这一调查小组，通过协调努力，促进对成瘾性疾病及其治疗的科学理解）。这些目标将通过目前资助的研究工作来实现，并简要介绍了临床药理学研究，以说明候选人目前资助的工作。此外，本申请的资金将用于与年轻临床医生进行的试点研究，并提出了比较曲马多与丁丙诺啡治疗阿片类药物戒断的研究计划。这项工作与NIH和NIDA的使命高度相关。需要招募和培训成瘾领域的年轻临床研究人员，以促进对这些疾病的理解和治疗。申请人有能力招募年轻的临床研究者，有成功指导年轻研究人员的经验，并且处于强大的研究环境中，拥有优秀的指导资源和提供高质量的临床研究经验。