Mentoring of Clinical Investigators in Patient Oriented Research

描述(由申请者提供)：这是一份申请K24以患者为中心的研究(POR)职业中期研究员奖的申请书。申请者是约翰·霍普金斯大学医学院精神病学系的内科研究员埃里克·斯特拉特。斯特雷克博士致力于POR，特别是与药物滥用研究和药物滥用患者治疗相关的问题。他的重点领域包括开发治疗阿片类药物和可卡因依赖的药物，结合行为治疗干预的药物测试，精神症状和共病在药物使用障碍中的作用，药物滥用易感性的测试，以及有药物滥用的女性和男性的特殊治疗需求。这份申请书描述了应聘者的三个直接职业目标(招募年轻的医生/临床研究人员进行临床成瘾研究的研究奖学金，通过在临床调查的所有方面提供直接经验，将这些临床研究人员整合到BPRU进行的POR正在进行的和新的研究中，以及在从同事过渡到初级教员的过程中帮助和指导这些临床研究人员，鼓励每个人继续进行与成瘾相关的研究的职业道路)。此外，还描述了三个长期职业目标(培养一批具有进行成瘾相关研究专业知识的初级、中级和高级临床医生调查员，作为约翰·霍普金斯大学药物滥用研究的下一代调查员，保持BPRU目前的调查实力，同时通过研究界的合作努力建立新的临床研究互补领域，并通过协调努力利用这一调查团队促进对成瘾障碍及其治疗的科学理解)。这些目标将通过目前资助的研究努力实现，并简要介绍一项临床药理学研究，以说明目前由候选人资助的工作。此外，本次申请的资金将用于与年轻临床医生进行的试点研究，并提出了一项比较曲马多和丁丙诺啡治疗阿片类药物戒断的研究计划。这项工作与NIH和NIDA的使命高度相关。需要招募和培训成瘾领域的年轻临床研究人员，以促进对这些疾病的了解和治疗。申请人具备招聘年轻临床研究人员的有利条件，拥有成功指导年轻研究人员的经验，并处于强大的研究环境中，拥有良好的指导资源和提供高质量的临床研究经验。

DESCRIPTION (provided by applicant): This is an application for a K24 Mid-career Investigator Award in Patient Oriented Research (POR). The applicant is Eric Strain, a physician-researcher in the Department of Psychiatry at Johns Hopkins University School of Medicine. Dr. Strain has devoted his career to POR, and specifically to issues related to research on drug abuse and to treatment of substance abusing patients. His areas of focus have included the development of medications for the treatment of opioid and cocaine dependence, the testing of medications combined with behavioral treatment interventions, the role of psychiatric symptoms and comorbidity in substance use disorders, the testing of abuse liability of medications, and the special treatment needs of women and men with substance abuse. This application describes the candidate's three immediate career goals (to recruit young physicians/clinical investigators to conduct research fellowships in clinical addictions research, to integrate these clinical investigators into ongoing and new studies of POR conducted at the BPRU by providing direct experience in all aspects of clinical investigation, and to assist and mentor these clinical investigators in the transition from fellow to junior faculty member, encouraging each to continue in a career path of addictions-related research). In addition, three long-term career goals are also described (to develop a group of junior, mid-level, and senior clinician investigators with expertise in conducting addictions-related research to serve as a next generation of investigators in substance abuse research at Johns Hopkins, to maintain current investigative strengths of the BPRU while building new complementary areas of clinical research through collaborative efforts within the research community, and to utilize this investigative team in advancing scientific understanding of addictive disorders and their treatment through coordinated efforts). These goals will be accomplished through currently funded research efforts, and a clinical pharmacology study is succinctly presented to illustrate work currently funded by the candidate. In addition, funds from the present application will be used for pilot studies to be conducted with young clinicians, and the research plan for a study comparing tramadol to buprenorphine for the treatment of opioid withdrawal is presented. This work is highly relevant to the mission of NIH and NIDA. Recruiting and training young clinical investigators in the area of addictions are needed to advance understanding and treatment of these disorders. The applicant is well positioned to recruit young clinical investigators, has experience in successfully mentoring young researchers, and is in a strong research environment with excellent resources for mentoring and providing high quality clinical research experiences.