Mentoring of Clinical Investigators in Patient Oriented Research

描述(由申请人提供)：这是一份竞争续签申请，以患者为中心的研究(POR)中的K24职业中期研究员奖。申请者是约翰·霍普金斯大学医学院精神病学系的内科研究员埃里克·C·斯特拉特。斯特雷克博士致力于POR，特别是与药物滥用研究和药物滥用患者治疗相关的问题。他的重点领域包括(除其他外)治疗阿片类药物和可卡因依赖的药物开发，药物测试与行为治疗干预相结合，精神症状和共病在药物使用障碍中的作用，药物滥用责任测试，以及药物滥用女性和男性的特殊治疗需求。在过去五年为K24提供资金的过程中，他还将时间和精力转移到招募和发展对与物质使用障碍相关的POR感兴趣的研究员和初级教员上。他的工作环境非常好；他在一家主要的学术研究机构(约翰·霍普金斯大学)工作，他是一个富有成效的研究小组(行为药理学研究单位[BPRU])的成员，BPRU有一个完善的博士后研究员T32培训计划(由George Bigelow博士指导；候选人是该计划的教员，该K24的博士后导师已经注册并得到T32计划的支持)。候选人的职业目标和目的与成瘾相关POR领域下一代临床医生研究人员的发展有关；此外，候选人的个人目标与他自己持续的研究生产力有关(这将与他的指导活动同时发生，并促进指导过程)。他的近期目标和目标与 招募和发展年轻的临床研究人员，他们有潜力发展为独立资助的研究人员，致力于POR在成瘾方面的研究。此外，他还有更直接的目标，即通过同行评审的论文和科学报告来衡量持续的独立资金和生产率，并与对更广泛的成瘾科学领域的贡献有关(例如，通过编辑一本杂志，以及通过委员会的工作，如担任研究分部主席)。他的长期目标涉及在霍普金斯大学建立在成瘾领域工作的下一代临床医生学者，预计这项工作将继续进行，并将延长到本K24将提供的五年资金之后。候选人得到了他所在机构和部门领导层的大力支持，并致力于指导过程的所有特点(包括他自己的培训以及对受试者进行负责任的研究行为的培训)。他在NIH资助的研究方面有着强大和持续的记录，过去五年的K24资助表明，他能够成功地招聘到即将毕业的住院医师和心理学家，并帮助他们开始他们的临床研究生涯。这份申请提供了两个研究项目的例子；一个与候选人自己资助的工作有关，另一个与他的一个被辅导者的兴趣有关。总而言之，K24机制一直是支持这位候选人作为临床医生研究员和导师进行研究和成长的理想手段，对Dr.Stress的持续资助将在致力于以患者为导向的成瘾研究的下一代临床医生调查人员的发展中提供连续性和持续增长。

DESCRIPTION (provided by applicant): This is a competing renewal application for a K24 Midcareer Investigator Award in Patient-Oriented Research (POR). The applicant is Eric C. Strain, a physician-researcher in the Department of Psychiatry at Johns Hopkins University School of Medicine. Dr. Strain has devoted his career to POR, and specifically to issues related to research on drug abuse and to treatment of substance abusing patients. His areas of focus have included (among others) the development of medications for the treatment of opioid and cocaine dependence, the testing of medications combined with behavioral treatment interventions, the role of psychiatric symptoms and comorbidity in substance use disorders, the testing of abuse liability of medications, and the special treatment needs of women and men with substance abuse. Over the past five years of funding for this K24, he has also shifted time and effort to the recruitment and development of fellows and junior faculty members who are interested in POR related to substance use disorders. He is in an excellent environment for such work; he is at a major academic research institution (Johns Hopkins), he is a member of a productive research group (the Behavioral Pharmacology Research Unit [BPRU]), and the BPRU has a well-established T32 training program for post-doctoral fellows (directed by Dr. George Bigelow; the candidate is a faculty member of that program, and post-doctoral mentees for this K24 have been enrolled in and supported by the T32 program). The candidate's career goals and objectives are related to the development of a next generation of clinician investigators in addictions-related POR; in addition, the candidate's personal goals are related to his own continued research productivity (which will occur concurrent with his mentoring activities, and facilitate the mentoring process). His immediate goals and objectives relate to the recruitment and development of young clinical investigators who show potential to develop as independently funded investigators committed to POR in addictions. In addition, he has more immediate goals related to continued independent funding and productivity as measured by peer-reviewed papers and scientific presentations, and related to contributions to the broader field of addictions science (e.g., through editing of a journal, and through committee work such as chair of a study section). His longer-term goals relate to the establishment of the next generation of clinician scholars working in the area of addictions at Hopkins, which is expected to be ongoing and to extend beyond the five years of funding that would be provided by this K24. The candidate has the strong backing of his institution and departmental leadership, and is committed to all features of the mentoring process (including his own training as well as the training of mentees in the responsible conduct of research). He has a strong and sustained track record of NIH-funded research, and the past five years of K24 funding show that he has been able to successfully recruit graduating physician residents as well as psychologists and help them begin their clinical research careers. This application provides examples of two research projects; one related to the candidate's own funded work, and the second related to one of his mentee's interests. In summary, the K24 mechanism has been an ideal means for supporting this candidate's research and growth as a clinician investigator and mentor, and continued funding for Dr. Strain will provide continuity and continued growth in the development of a next generation of clinician investigators devoted to patient oriented research in addictions.