Examining an extracellular matrix regulator required for cardiovascular development

检查心血管发育所需的细胞外基质调节剂

• 批准号: nhmrc : 1106800
• 负责人: Dr Kelly Smith
• 金额: $ 50.41万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/examining-an-extracellular-cardiovascular-development/662936
• 关键词: Examining; extracellular; matrix; regulator; required

Cardiovascular disease (CVD) is the highest cause of death in Australia. Specific genes are required for correct assembly and function of the heart and vessels but disease will result if those genes are defective. To diagnose and treat CVD, we must first understand how these genes function. This project will investigate mouse models with genetic defects resulting in CVD. It will determine how and why the diseases occur and investigate a potential therapeutic option for intervention in CVD.

心血管疾病（CVD）是澳大利亚最大的死亡原因。心脏和血管的正确组装和功能需要特定的基因，但如果这些基因有缺陷，就会导致疾病。为了诊断和治疗心血管疾病，我们必须首先了解这些基因的功能。该项目将研究导致心血管疾病的遗传缺陷小鼠模型。它将确定疾病发生的方式和原因，并研究心血管疾病干预的潜在治疗选择。