An Electrical Impedance Monitor

电阻抗监测仪

• 批准号: 6788909
• 负责人: Justin S Clark
• 金额: $ 10万
• 依托单位: MEDICAL PHYSICS, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-21 至 2005-05-20
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6788909
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; biosensor device; blood cell count; clinical biomedical equipment; clinical research; computer program /software; electrical impedance; electrodes; human tissue; microprocessor /microchip; noninvasive diagnosis; patient monitoring device; portable biomedical equipment

DESCRIPTION (provided by applicant): Knowledge of Hematocrit (Hct) is important in several chronic and critical care situations. Presently, Hct measurement requires finger sticks, heel sticks, and blood withdrawals, causing patient trauma as a result of such blood sampling. The development of noninvasive Hct measurement instrument is proposed which will eliminate the trauma of present invasive measurement methods as well as provide immediate results. The method relies upon the sensitivity of the electrical impedance of blood to hematocrit, which differs at high and low frequencies. This principle has been used successfully to measure hematocrit in vitro and in pulse oximetry. The method should be ideal as a screening tool for prospective blood donors as well as for applications in doctors' offices. Since this is a monitoring instrument that provides a continuous measurement, patients in surgery or critical care would benefit from the immediacy of the results compared to the time taken in waiting for lab test results. The tasks of Phase I are directed toward the development and validation of the method. Assuming a successful Phase I, a commercial prototype instrument will be designed and tested in the Phase II.

描述(由申请人提供)： 红细胞压积(Hct)的知识在几种慢性和危重情况下很重要。目前，Hct测量需要手指棒、脚后跟棒和抽血，这样的采血会给患者带来创伤。提出了一种无创血细胞比容测量仪的研制，它将消除现有有创测量方法的创伤，并提供即时的结果。该方法依赖于血液的电阻抗对红细胞压积的敏感性，这种敏感性在高频和低频下是不同的。该原理已成功地用于体外和脉搏血氧饱和度的测量。该方法应该是对潜在献血者以及医生办公室应用程序的理想筛查工具。由于这是一种提供连续测量的监测仪器，与等待实验室测试结果所需的时间相比，手术或危重护理中的患者将受益于结果的即时性。第一阶段的任务是针对该方法的开发和验证。假设第一阶段成功，商业原型仪器将在第二阶段设计和测试。