Bloodless Blood Gas and pH Monitor

无血血气和 pH 监测仪

• 批准号: 6692765
• 负责人: Justin S Clark
• 金额: $ 9.64万
• 依托单位: MEDICAL PHYSICS, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2005-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6692765
• 关键词: acidity /alkalinity; biomedical equipment development; blood chemistry; clinical research; hemodynamics; human subject; noninvasive diagnosis; patient monitoring device; patient oriented research; respiratory gas analyzer

DESCRIPTION (provided by applicant): Medical Physics is engaged in the development of noninvasive methods of extracting hemodynamic data, normally only accessible by use of highly invasive right heart catheterizations. The methods employ inert gases, in tracer concentrations, applied at the airway and measured at the nose by a gas analyzer specifically developed for this purpose. Recently, we have discovered that by adding stable (non-radioactive) tracers of oxygen and carbon dioxide to the tracer mix, arterial blood gas and pH measurements can also be obtained noninvasively -which if sufficiently accurate - could eliminate the need for arterial sticks (which have associated long lasting pain), commonly used to obtain arterial blood samples for blood gas and pH analysis by the blood gas laboratory. Additionally, the new method could routinely provide measurements of mixed venous oxygen content, a parameter which currently requires access to blood by a right heart catheter. Therefore, by eliminating the need for arterial sticks and/or central venous catheterizations, blood gas and pH measurements, would be available to a wider range of patients. These include patients in clinics and small rural hospitals which may not have well equipped blood gas laboratories or well trained personnel to operate them on a twenty-four hour basis. Therefore, a goal of this project is to demonstrate that noninvasive pH and blood gas measurements can be made with sufficient accuracy to meet clinical standards. A second goal is to demonstrate that hardware requirements of the monitor can meet the economic constraints of the blood gas industry.

描述（由申请人提供）： 医学物理学致力于开发提取血液动力学数据的非侵入性方法，通常只能通过使用高侵入性右心导管插入术获得。该方法采用惰性气体，在示踪剂浓度，应用在气道和测量在鼻子的气体分析仪专门为此目的而开发。最近，我们已经发现，通过向示踪剂混合物中添加稳定的（非放射性）氧气和二氧化碳示踪剂，也可以非侵入性地获得动脉血气和pH值测量结果-如果足够准确-可以消除对动脉棒的需要（其具有相关的长期持续疼痛），动脉棒通常用于获得动脉血液样本以供血气实验室进行血气和pH值分析。此外，新方法可以常规地提供混合静脉氧含量的测量，这是一个目前需要通过右心导管进入血液的参数。因此，通过消除对动脉穿刺和/或中心静脉导管插入术的需要，血气和pH测量将可用于更广泛的患者。这包括诊所和农村小医院的病人，这些医院可能没有装备精良的血气实验室或训练有素的人员24小时操作这些实验室。因此，本项目的目标是证明可以进行无创pH和血气测量，其精度足以满足临床标准。第二个目标是证明监护仪的硬件要求可以满足血气行业的经济限制。