Bloodless Blood Gas and pH Monitor

描述(由申请人提供)： 医学物理学致力于开发提取血流动力学数据的非侵入性方法，通常只有通过使用高侵入性的右心导管才能获得。这些方法使用具有示踪剂浓度的惰性气体，应用于呼吸道，并由专门为此目的开发的气体分析仪在鼻子处进行测量。最近，我们发现，通过在示踪剂混合物中添加稳定的(非放射性)氧气和二氧化碳示踪剂，也可以非侵入性地获得动脉血气和pH值测量-如果足够准确-可以消除对动脉棒的需要(这会导致长期的疼痛)，动脉棒通常用于获取动脉血样用于血气和血气实验室的pH值分析。此外，新方法可以常规提供混合静脉含氧量的测量，这是目前需要通过右心导管进入血液的参数。因此，通过消除对动脉棒和/或中心静脉插管的需要，血气和pH测量将适用于更广泛的患者。这些患者包括诊所和小型乡村医院的患者，这些医院可能没有设备齐全的血气实验室或训练有素的人员24小时进行操作。因此，该项目的一个目标是证明非侵入性pH和血气测量可以以足够的精度进行，以满足临床标准。第二个目标是证明监护仪的硬件要求可以满足血气行业的经济约束。

DESCRIPTION (provided by applicant): Medical Physics is engaged in the development of noninvasive methods of extracting hemodynamic data, normally only accessible by use of highly invasive right heart catheterizations. The methods employ inert gases, in tracer concentrations, applied at the airway and measured at the nose by a gas analyzer specifically developed for this purpose. Recently, we have discovered that by adding stable (non-radioactive) tracers of oxygen and carbon dioxide to the tracer mix, arterial blood gas and pH measurements can also be obtained noninvasively -which if sufficiently accurate - could eliminate the need for arterial sticks (which have associated long lasting pain), commonly used to obtain arterial blood samples for blood gas and pH analysis by the blood gas laboratory. Additionally, the new method could routinely provide measurements of mixed venous oxygen content, a parameter which currently requires access to blood by a right heart catheter. Therefore, by eliminating the need for arterial sticks and/or central venous catheterizations, blood gas and pH measurements, would be available to a wider range of patients. These include patients in clinics and small rural hospitals which may not have well equipped blood gas laboratories or well trained personnel to operate them on a twenty-four hour basis. Therefore, a goal of this project is to demonstrate that noninvasive pH and blood gas measurements can be made with sufficient accuracy to meet clinical standards. A second goal is to demonstrate that hardware requirements of the monitor can meet the economic constraints of the blood gas industry.