MATHEMATICAL MODEL FOR RENAL TRANSPLANT EVALUATION

肾移植评估的数学模型

• 批准号: 3496069
• 负责人: Justin S Clark
• 金额: $ 5万
• 依托单位: MEDICAL PHYSICS, INC.
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-02-15 至 1992-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3496069
• 关键词: computer program /software; diagnosis design /evaluation; human therapy evaluation; kidney disorder diagnosis; kidney function; kidney transplantation; mathematical model; model design /development; radiotracer; statistics /biometry

DESCRIPTION (Adapted from the Applicant's Abstract): Although renal transplantation has proved to be both useful and cost-effective compared to dialysis, complications are frequent. Much of the success of renal transplantation is dependent upon prompt identification of the cause of impairment of function so that appropriate treatment can be applied before the condition becomes irreversible. Although nuclear medicine systems and several methods of analysis are available to evaluate kidney function, currently no evaluation system exists which combines information from all segments of the time-activity curve to provide a global assessment of renal function. An improved means of radionuclide renogram analysis would contribute to earlier diagnosis, improved accuracy of diagnosis, and reduced need for biopsies; an automated program would save technologists time and, thereby, make detail analysis practicable; presenting results as probability of diagnosis in each category would be very helpful to clinicians and would make the degree of assurance of the diagnosis clear; from this sort of presentation rational criteria for doing biopsies should evolve. The investigators in this project propose to develop and evaluate a comprehensive mathematical, physiologic model which will include all phases of the time-activity curve in performing a global analysis of renal function. Coefficients will be derived representing rate and concentration data corresponding to the transit of the tracer through the various compartments of the kidney. These coefficients will be correlated with the diagnoses of individual cases. Software will be developed in such a way that it should be applicable to the usual nuclear medicine computers or to the work stations linked to them. Thus, if successful, the product should be widely applicable to any facility with a renal transplant program desiring analytical treatment of radionuclide transplant evaluations.

描述（改编自申请人摘要）：尽管肾 移植已被证明是有用的和成本效益相比， 透析并发症频发。 肾移植的大部分成功 移植依赖于及时识别的原因， 功能受损，以便在进行适当治疗之前 病情就不可逆转了 虽然核医学系统和 有几种分析方法可用于评价肾功能， 目前还没有一个评估系统， 时间-活动曲线的分段，以提供对 肾功能 一种改进的放射性核素肾图分析方法将 有助于早期诊断，提高诊断的准确性， 减少活检的需要;自动化程序将节省技术人员 时间，从而使详细的分析切实可行;提出的结果， 每个类别的诊断概率将非常有助于 临床医生，并会作出明确的诊断保证程度; 从这种表现来看，做活检的合理标准应该是 进化 该项目的研究人员建议开发和评估 一个全面的数学、生理模型，其中包括所有 时间-活性曲线的相位在进行肾功能的整体分析中的应用 功能 将导出代表速率的系数， 对应于示踪剂通过微通道的传输的浓度数据。 肾脏的不同部分 这些系数将相互关联 与个别病例的诊断相联系。 软件将在 这种方法应该适用于通常的核医学 计算机或与之相连的工作站。 如果成功， 该产品应广泛适用于任何具有肾 需要放射性核素分析处理的移植程序 移植评估