Noninvasive Arterial Blood Gas Standard

无创动脉血气标准

• 批准号: 7326754
• 负责人: Justin S Clark
• 金额: $ 10.57万
• 依托单位: MEDICAL PHYSICS, INC.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-26 至 2009-03-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7326754
• 关键词: Adult; Affect; Blood; Blood gas; Blood specimen; Bulla; Calibration; Carbon Dioxide; Characteristics; Chemicals; Clinical; Complement component C1s; Condition; Cutaneous; Data; Development; Devices; Diffusion; Electrodes; Electrolytes; Elements; Environmental air flow; Equilibrium; Gases; Goals; Hand; Heterogeneity; Invasive; Laboratories; Measurement; Measures; Metabolic; Metabolism; Methods; Monitor; Newborn Infant; Oxygen; Patients; Performance; Perfusion; Personal Satisfaction; Phase; Physiologic pulse; PtcO2; Pulse Oximetry; Pulse taking; Range; Severities; Site; Skin; Solutions; Standards of Weights and Measures; Technology; Temperature; Time; Tissues; Vascular blood supply; Ventilator; concept; hemodynamics; indexing; pressure; sensor

DESCRIPTION (provided by applicant): Blood gases are by far the most frequently monitored chemical parameters. Arterial oxygen (PaO2) is needed to assess the efficiency of O2 exchange. Arterial carbon dioxide (PaCO2) is needed to assess efficiency of ventilation and is most useful for ventilator management. However, because arterial blood sampling is not practical in many clinical situations, there is a need for noninvasive blood gas monitoring which does not rely on laboratory measurements for references. This proposal introduces a new concept for a noninvasive arterial blood monitor which applies metabolic correction applied to transcutaneous carbon dioxide measurements. The correction is derived from cutaneous oxygen metabolism data obtained from the differences of arterial and transcutaneous oxygen measurements at the site of the cutaneous carbon dioxide sensor. The new principle incorporates automatic calibration of cutaneous measurements and a sufficiently low skin contact temperature, to eliminate the need for periodic relocation of the measuring device. The arterial oxygen measurement utilizes a new concept of pressure enhancement applied to pulse oximetry. Because arterial blood sampling is not practical in many clinical situations, there is a need for noninvasive blood gas monitoring which does not rely on laboratory measurements for references. The overall goal of the project is to develop a monitor which can provide accurate and reliable blood gas data, noninvasively, without need for additional laboratory measurements for reference.

描述（由申请人提供）：血气是迄今为止最常监测的化学参数。需要动脉氧 (PaO2) 来评估 O2 交换的效率。动脉二氧化碳 (PaCO2) 是评估通气效率所必需的，对于呼吸机管理最有用。然而，由于动脉血采样在许多临床情况下并不实用，因此需要不依赖实验室测量作为参考的无创血气监测。该提案引入了无创动脉血监测仪的新概念，该监测仪将代谢校正应用于经皮二氧化碳测量。该校正源自皮肤氧代谢数据，该数据是从皮肤二氧化碳传感器部位的动脉和经皮氧测量的差异获得的。新原理结合了皮肤测量的自动校准和足够低的皮肤接触温度，从而无需定期重新定位测量设备。动脉氧测量采用了应用于脉搏血氧测定法的压力增强的新概念。由于动脉血采样在许多临床情况下并不实用，因此需要不依赖实验室测量作为参考的无创血气监测。该项目的总体目标是开发一种监测仪，能够无创地提供准确可靠的血气数据，无需额外的实验室测量作为参考。