Swine in Biomedical Research conference

描述(由申请人提供)： 这次会议将突出猪模型在生物医学研究中日益增长的实用价值。在工具箱类别中，基因组和组织微阵列刚刚开始被用于动物模型。随着猪特有的基因组信息变得越来越可用，在许多疾病类别中描述和采用猪作为人类模型的速度将会加快。在应用类别中，除了猪在免疫学、营养学、移植、心血管疾病、骨科和皮肤科/伤口愈合方面已经被证明的价值之外，还有很多东西需要探索。此外，还需要在新的人畜共患疾病、生物防御、行为/神经成像和灵知生物学方面采取行动。猪的基因组也在测序中，将提供可用于构建相关模型的序列信息。捕捉序列信息以创建适当的模型来研究发病机制，诊断和治疗与生活方式相关的疾病的新方法现在在猪身上成为现实。随着供体器官的日益短缺，人们开始寻找合适的异种移植器官。猪现在被认为是主要的候选捐献动物。对猪进行基因改造和克隆的能力为进一步利用这一模型提供了一个独特的机会，不仅可以理解移植排斥的机制，还可以创造临床治疗方法。会议的目标是确定将提高猪作为生物医学模型的实用性的研究领域或方法。特别是，会议将侧重于确定传统啮齿动物模型被证明不相关的适当人类疾病，在这方面可以加强猪的历史使用，或者在今天不存在有用的模型的情况下，可以考虑使用猪。会议将确定资源需求和需要新的方针或方法的领域。会议还将促进猪和人类基因组学领域的研究人员之间的互动，并确定充分利用这一动物模型的需求和机会。

DESCRIPTION (provided by applicant): The conference will highlight the growing utility of swine models in biomedical research. In the toolbox category, genomic and tissue microarrays are just beginning to be appreciated for use in animal models. As porcine-specific genomic information becomes increasingly available, characterization and adoption of pigs as human models in many disease categories will accelerate. In the applications category, there is still much to explore beyond the pig's already proven value in immunology, nutrition, transplantation, cardiovascular disease, orthopedics, and dermatology/wound healing. In addition, initiatives are warranted in new zoonotic diseases, biodefense, behavior/neurological imaging, and gnotobiology. The pig genome is also being sequenced and will provide sequence information that can be used to construct relevant models. Capturing sequence information to create appropriate models to study pathogenesis, new means of diagnosing and treating life style-related diseases are now a reality with the pig. The increasing shortage of donor organs for transplantation has lead to a search for suitable xenograft organs. Pigs are now considered the primary candidate donor animal. The ability to genetically modify and clone pigs provides a unique opportunity to further exploit this model not only for understanding the mechanisms of graft rejection but to create clinical therapies. The conference goals are to identify areas of study or methodologies that will enhance the utility of pigs as biomedical models. In particular, the conference will focus on identifying appropriate human diseases where traditional rodent models have not proven relevant, where the historical use of swine in this regard may be enhanced, or where no useful models exist today and for which swine may be considered. The conference will identify resource needs and areas in which new approaches or methodologies are required. The conference also will serve to stimulate interactions between researchers working within swine and human genomics and identify needs and opportunities to fully exploit this animal model.