Swine in Biomedical Research conference

猪生物医学研究会议

• 批准号: 6838024
• 负责人: LAWRENCE B SCHOOK
• 金额: $ 2.25万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6838024
• 关键词: biological models; disease /disorder model; meeting /conference /symposium; swine; travel; xenotransplantation

DESCRIPTION (provided by applicant): The conference will highlight the growing utility of swine models in biomedical research. In the toolbox category, genomic and tissue microarrays are just beginning to be appreciated for use in animal models. As porcine-specific genomic information becomes increasingly available, characterization and adoption of pigs as human models in many disease categories will accelerate. In the applications category, there is still much to explore beyond the pig's already proven value in immunology, nutrition, transplantation, cardiovascular disease, orthopedics, and dermatology/wound healing. In addition, initiatives are warranted in new zoonotic diseases, biodefense, behavior/neurological imaging, and gnotobiology. The pig genome is also being sequenced and will provide sequence information that can be used to construct relevant models. Capturing sequence information to create appropriate models to study pathogenesis, new means of diagnosing and treating life style-related diseases are now a reality with the pig. The increasing shortage of donor organs for transplantation has lead to a search for suitable xenograft organs. Pigs are now considered the primary candidate donor animal. The ability to genetically modify and clone pigs provides a unique opportunity to further exploit this model not only for understanding the mechanisms of graft rejection but to create clinical therapies. The conference goals are to identify areas of study or methodologies that will enhance the utility of pigs as biomedical models. In particular, the conference will focus on identifying appropriate human diseases where traditional rodent models have not proven relevant, where the historical use of swine in this regard may be enhanced, or where no useful models exist today and for which swine may be considered. The conference will identify resource needs and areas in which new approaches or methodologies are required. The conference also will serve to stimulate interactions between researchers working within swine and human genomics and identify needs and opportunities to fully exploit this animal model.

描述（由申请人提供）： 会议将强调猪模型在生物医学研究中日益增长的实用性。在工具箱类别中，基因组和组织微阵列在动物模型中的使用刚刚开始受到重视。随着猪特异性基因组信息的日益普及，猪作为许多疾病类别的人类模型的表征和采用将会加速。在应用领域，除了猪在免疫学、营养学、移植、心血管疾病、骨科和皮肤病学/伤口愈合方面已被证实的价值之外，还有很多值得探索的地方。此外，在新的人畜共患疾病、生物防御、行为/神经成像和侏儒生物学方面也有必要采取举措。猪基因组也正在进行测序，并将提供可用于构建相关模型的序列信息。捕获序列信息以创建适当的模型来研究发病机制，诊断和治疗与生活方式相关的疾病的新方法现已在猪身上成为现实。用于移植的供体器官的日益短缺导致人们寻找合适的异种移植器官。猪现在被认为是主要的候选捐赠动物。基因改造和克隆猪的能力提供了一个独特的机会，可以进一步利用该模型，不仅可以了解移植排斥机制，还可以创造临床疗法。会议的目标是确定可增强猪作为生物医学模型的实用性的研究领域或方法。特别是，会议将重点确定传统啮齿动物模型尚未证明相关的适当人类疾病，猪在这方面的历史使用可能会得到加强，或者目前不存在有用的模型而可以考虑使用猪。会议将确定资源需求以及需要新方法或方法的领域。该会议还将促进猪和人类基因组学研究人员之间的互动，并确定充分利用这种动物模型的需求和机会。