Swine in Biomedical Research Conference 2011 Creating the Building Blocks: Genomi

描述（由申请人提供）：2011年猪生物医学研究会议将突出猪模型在生物医学研究中日益增长的实用性。在工具箱类别中，基因组和组织微阵列以及下一代测序才刚刚开始受到重视。在应用类别中，除了猪在免疫学、营养学、移植、心血管疾病和整形外科方面已经证明的价值之外，还有很多东西需要探索。在人畜共患疾病、认知行为、生物工程和再生医学方面有必要采取新的举措。猪的基因组已经完成，序列信息可以用于构建模型，以开发诊断和治疗生活方式相关疾病的新方法。基因修饰和克隆猪的能力进一步提高了猪在剖析疾病机制和验证临床治疗方面的价值。最近的研讨会集中在利用传统上由美国农业部支持的动物科学专业知识，可以支持NIH资助的研究人员利用猪模型。这些美国农业部和国家卫生研究院的联合讨论确定了文化差异和缺乏对需求和机会的深入了解是主要的利率限制问题。因此，组织这次会议是为了直接解决这些公认的局限性。首先，组织委员会选择了其研究成功超越健康和动物科学文化的个人。其次，受邀演讲者将展示使用猪的研究，这些研究展示了成功的应用以及需要跨越拟议文化鸿沟参与的有前途的领域。最后，我们将邀请美国农业部和美国国立卫生研究院的代表领导关于整合各自优势以解决关键生物医学研究问题的讨论。 公共卫生相关性（由申请人提供）：2011年猪生物医学研究会议是一系列及时会议中的第四次会议，这些会议强调了猪模型在生物医学研究中的实用性。遗传信息和靶向操作技术的出现与克隆猪的能力相结合，提供了创建高度相关的动物模型的能力。这次会议将建立在生物医学界关于猪的利用的相当大的能量。

DESCRIPTION (provided by applicant): The Swine in Biomedical Research Conference 2011 will highlight the growing utility of swine models in biomedical research. In the toolbox category, genomic and tissue microarrays and next generation sequencing are just beginning to be appreciated. In the applications category, there is still much to explore beyond the pig's already proven value in immunology, nutrition, transplantation, cardiovascular disease, and orthopedics. New initiatives are warranted in zoonotic diseases, cognitive behavior, bioengineering and regenerative medicine. The pig genome has been completed and sequence information can be used to construct models to development new means of diagnosing and treating life style-related diseases. The ability to genetically modify and clone pigs further enhances the value of the pig for dissecting disease mechanisms and validating clinical therapies. Recent workshops have focused on utilizing animal sciences expertise traditionally supported by the USDA can support of NIH funded investigators that utilizing pig models. These joint USDA and NIH discussions identified cultural differences and the lack of in depth knowledge of needs and opportunities as major rate limiting issues. Hence, this conference has been organized to directly address these acknowledged limitations. First, the Organizing Committee has selected individuals whose research has successfully transcended both health and animal science cultures. Second, the invited speakers will showcase investigations using the pig that demonstrate successful applications as well as promising areas that require engagement across the proposed cultural divide. Finally, we will invite USDA and NIH representations to lead discussions on integrating respective strengths into addressing critical biomedical research issues. PUBLIC HEALTH RELEVANCE (provided by applicant): The Swine in Biomedical Research Conference 2011 represents the fourth in a series of timely conferences that have highlighted the utility of porcine models in biomedical research. The emergence of genetic information and the technologies to target manipulations combined with the ability to clone pigs provides the ability to create highly relevant animal model. This conference will build upon the considerable energy within the biomedical community with respect to the utilization of pigs.