Swine in Biomedical Research Conference 2011 Creating the Building Blocks: Genomi

描述（由申请人提供）：2011年生猪生物医学研究会议将重点介绍生猪模型在生物医学研究中的日益增长的效用。在工具箱类别中，基因组和组织微阵列以及下一代测序才刚刚开始受到重视。在应用方面，除了猪在免疫学、营养学、移植、心血管疾病和骨科方面已经证明的价值之外，还有很多需要探索的地方。在人畜共患疾病、认知行为、生物工程和再生医学方面有必要采取新的举措。猪基因组已经完成，序列信息可用于构建模型，开发诊断和治疗生活方式相关疾病的新手段。基因修饰和克隆猪的能力进一步提高了猪在解剖疾病机制和验证临床治疗方面的价值。最近的研讨会集中在利用传统上由美国农业部支持的动物科学专业知识，可以支持美国国立卫生研究院资助的利用猪模型的研究人员。这些美国农业部和美国国立卫生研究院的联合讨论确定了文化差异和缺乏对需求和机会的深入了解是主要的限速问题。因此，组织这次会议是为了直接解决这些公认的限制。首先，组委会选择了研究成功超越健康和动物科学文化的个人。其次，受邀的演讲者将展示使用猪进行的调查，这些调查展示了成功的应用，以及需要跨越拟议的文化鸿沟的有前途的领域。最后，我们将邀请美国农业部和美国国立卫生研究院的代表就整合各自的优势来解决关键的生物医学研究问题进行讨论。

DESCRIPTION (provided by applicant): The Swine in Biomedical Research Conference 2011 will highlight the growing utility of swine models in biomedical research. In the toolbox category, genomic and tissue microarrays and next generation sequencing are just beginning to be appreciated. In the applications category, there is still much to explore beyond the pig's already proven value in immunology, nutrition, transplantation, cardiovascular disease, and orthopedics. New initiatives are warranted in zoonotic diseases, cognitive behavior, bioengineering and regenerative medicine. The pig genome has been completed and sequence information can be used to construct models to development new means of diagnosing and treating life style-related diseases. The ability to genetically modify and clone pigs further enhances the value of the pig for dissecting disease mechanisms and validating clinical therapies. Recent workshops have focused on utilizing animal sciences expertise traditionally supported by the USDA can support of NIH funded investigators that utilizing pig models. These joint USDA and NIH discussions identified cultural differences and the lack of in depth knowledge of needs and opportunities as major rate limiting issues. Hence, this conference has been organized to directly address these acknowledged limitations. First, the Organizing Committee has selected individuals whose research has successfully transcended both health and animal science cultures. Second, the invited speakers will showcase investigations using the pig that demonstrate successful applications as well as promising areas that require engagement across the proposed cultural divide. Finally, we will invite USDA and NIH representations to lead discussions on integrating respective strengths into addressing critical biomedical research issues. PUBLIC HEALTH RELEVANCE (provided by applicant): The Swine in Biomedical Research Conference 2011 represents the fourth in a series of timely conferences that have highlighted the utility of porcine models in biomedical research. The emergence of genetic information and the technologies to target manipulations combined with the ability to clone pigs provides the ability to create highly relevant animal model. This conference will build upon the considerable energy within the biomedical community with respect to the utilization of pigs.