4Th Annual Mutant Mouse Regional Resource Center Meeting

描述（由申请人提供）： 为了满足科学界对突变小鼠进行生物医学研究的日益增长的需求，国家研究资源中心（NCRR）/NIH的比较医学计划（CMP）建立了四个突变小鼠区域资源中心（MMRRCs）和一个连接四个中心的电子网络（信息学协调中心- ICC）。MMRRCs的目标是开发能够进行饲养、冷冻保存、再衍生、表型表征、维护小鼠资源数据库以及提供高水平遗传和微生物质量控制的突变小鼠分布设施。U42资助机制还支持每个MMRRC的应用研究，旨在改善资源并加强NIH生物医学研究企业。MMRRC网络建立于1999年，这一复杂项目的管理和物流已经优化，小鼠正在提交给MMRRC，小鼠现在可以分发。 这项建议要求支持将于2004年3月举行的千年发展目标监测和报告资源中心第四次年度会议。会议将为MMRRC项目主任、ICC项目主任、外部指导委员会、MMRRC小组委员会主席和其他关键MMRRC人员提供一个论坛，与NCRR项目工作人员会面，讨论与推进MMRRC和NCRR项目目标有关的问题。此外，会议将为其他NIH项目人员提供一个论坛，为MMRRC概念提供投入，并与代表NCI的科学小鼠社区的主要代表协调工作（癌症的小鼠模型），化学诱变小鼠，基因捕获/胚胎干细胞小鼠档案，CRE-LoxP小鼠，今年的会议将是11/2天，将包括一个与实验室小鼠相关的科学计划。因此，会议的一部分将向一般科学界开放。拟议的会议将确保MMRRC计划的持续成功，为改进计划提供投入，并为科学和专业界提供教育论坛，以符合MMRRC和NCRR的计划目标。

DESCRIPTION (provided by applicant): In response to the growing demand of the scientific community to have access to mutant mice for biomedical research, the Comparative Medicine Program (CMP) of the National Center for Research Resources (NCRR)/NIH has established four Mutant Mouse Regional Resource Centers (MMRRCs) and an electronic network that links the four centers (the Informatics Coordinating Center - ICC). The goals of the MMRRCs are to develop mutant mouse distribution facilities capable of husbandry, cryopreservation, rederivation, phenotypic characterization, maintenance of a mouse resource database and a provision of high-level genetic and microbial quality control. The U42 funding mechanism also supports applied research at each of the MMRRCs that is intended to improve the resource and enhance the NIH biomedical research enterprise. The MMRRC network was established in 1999, the governance and logistics of this complex program have been optimized, mice are being submitted to the MMRRCs and mice are now available for distribution. This proposal requests support for the fourth Annual MMRRC Meeting to be held in March of 2004. The meeting will provide a forum for the MMRRC Program Directors, the ICC Program Director, an External Steering Committee, MMRRC Subcommittee Chairpersons, and other key MMRRC personnel to meet with NCRR program staff to discuss issues relating to advancing the MMRRC and NCRR program goals. In addition, the meeting will provide a forum for other NIH program staff to provide input into the MMRRC concept, and to coordinate efforts with the key representatives of the scientific mouse community, representing NCI (mouse models of cancer), chemically mutagenized mice, gene trapping/embryonic stem cell mouse archives, CRE-LoxP mice, etc. This year's meeting will be 11/2 days and will include a scientific program with relevance to the laboratory mouse. Thus, a portion of the meeting will be open to the general scientific community. The proposed meeting will assure the continued success of the MMRRC program, allow input into improving the program and to provide an educational forum for the scientific and professional community, in keeping with the program aims of the MMRRCs and the NCRR.