Hemorrhagic Brain Injury Repair with Human Cord Blood

描述(由申请人提供)：人脐血(HUCB)是一种丰富的干细胞来源，具有多能特性。以往的研究表明，在适当的环境条件下，人脐血细胞可以分化为神经细胞。赛隆CCEL公司正专注于使用hUCB作为一种治疗方法来治疗各种神经疾病。在这项I期STTR研究中，我们将评估人脐血对实验性出血性脑损伤的治疗效果。 脑出血(ICH)是发病率和死亡率的主要原因。幸存下来的患者往往严重残疾，照顾这些人的成本很高。 改善脑出血患者的功能将显著提高他们的生活质量，并降低护理成本。我们将评估静脉注射hUCB对胶原酶诱导的大鼠纹状体脑出血的影响。在出血诱导后的不同时间段给予hUCB。然后，将定期对动物进行评估，以评估它们随着时间的推移的神经状态。将对接受hUCB治疗的动物和接受其他类型假治疗的动物进行比较。在神经学评估之后，将对每只动物的脑组织进行组织学研究，以确定在出血脑环境中，人脐血细胞是否分化为神经细胞。这项研究的结果将为hUCB是否可用于治疗出血性脑损伤提供信息。

DESCRIPTION (provided by applicant): Human umbilical cord blood (hUCB) is a rich source of stem cells that exhibit multipotent properties. Previous studies have shown that hUCB cells can differentiate into neural cells under the appropriate environment conditions. SANERON CCEL, Inc. is focusing on the use of hUCB as a therapeutic approach for treating a variety of neurological disorders. In this Phase I STTR study we will evaluate the efficacy of using hUCB in treating experimental hemorrhagic brain injury. Intracerebral hemorrhage (ICH) is a major cause of morbidity and mortality. Patients who survive are often left severely disabled, and the costs for caring for these individuals are substantial. Improvements in function for patients with ICH would add significantly to their quality of life and reduce the cost for care. We will evaluate the effects of administering hUCB intravenously into rats with collagenase-induced ICH of the striatum. hUCB will be given at various time periods after the induction of the hemorrhage. Animals will then be evaluated periodically to assess their neurological status over time. Comparisons will be made between hUCB treated animals and those receiving other types of sham therapy. After the neurological assessments, brain tissue from each animal will be studied histologically to determine whether hUCB cells differentiated into neural cells within the environment of the hemorrhagic brain. The results from this study will provide information on whether hUCB can be used as a therapy for treating hemorrhagic brain injury.