Core--Neurological services

核心--神经科服务

• 批准号: 6861205
• 负责人: WALTER C LOW
• 金额: $ 9.57万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6861205
• 关键词: behavior test; behavioral /social science research tag; biomedical facility; cerebellar ataxia /dyskinesia; gene delivery system; genetic strain; laboratory mouse; mucopolysaccharidosis; neurosurgery

The Neurological Services Core for this program project grant will provide support for the surgical delivery of therapeutic gene constructs into the brain of MPS I, MPS VII, and SCA1 mice. In addition, this core will be involved in the neurologic assessment of cognitive and motor functions in these animals, and neurohistological assessments after the targeted surgical delivery of the therapeutic gene constructs.

该计划项目资助的神经学服务核心将为将治疗性基因构建体通过手术输送到MPS I、MPS VII和SCA 1小鼠的大脑中提供支持。此外，该核心将参与这些动物的认知和运动功能的神经学评估，以及治疗性基因构建体靶向手术递送后的神经组织学评估。