Chitosan hemostatic device for laparoscopic applications

腹腔镜应用壳聚糖止血装置

• 批准号: 6990303
• 负责人: HUA XIE
• 金额: $ 23.2万
• 依托单位: HEMCON, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6990303
• 关键词: biomedical equipment development; blood coagulation; chitin; clinical biomedical equipment; hemorrhage; hemostatics; laparoscopy; medical complication; nephrectomy; swine

DESCRIPTION (provided by applicant): Intraoperative bleeding can be a serious problem in parenchymal organ surgery and is generally difficult to manage during laparoscopic procedures. Our long-term goal is to develop a novel internal chitosan hemostatic device that can be deployed laparoscopically to control severe bleeding. External chitosan based hemostatic dressings have been applied successfully for control of aggressive hemorrhage in varying traumatic injuries. Based upon these successful studies, Phase I of this proposal includes 1) development of a novel internal chitosan hemostatic device; 2) optimization of the laparoscopic chitosan device and development of laparoscopic techniques for its delivery; and 3) evaluation of the laparoscopic hemostatic technique in partial nephrectomy. Phase II of the proposal, will expand upon the preliminary Phase I study. It will evaluate the efficacy of the internal chitosan hemostatic device in a large scale laparoscopic study. The proposed chitosan device(s) will provide safe, effective and convenient treatment to control surgical bleeding during the laparoscopic procedure and will prevent hemorrhage and urinary leakage related post-operative complications.

描述（由申请人提供）： 术中出血可能是实质器官手术中的严重问题，并且在腹腔镜手术中通常难以管理。我们的长期目标是开发一种新型的内部壳聚糖止血装置，可以部署在腹腔镜下控制严重出血。基于壳聚糖的外部止血敷料已成功应用于控制各种创伤性损伤中的侵袭性出血。基于这些成功的研究，该提案的I期包括1）开发一种新型内部壳聚糖止血器械; 2）优化腹腔镜壳聚糖器械并开发其输送的腹腔镜技术; 3）评价肾部分切除术中的腹腔镜止血技术。该提案的第二阶段将在初步的第一阶段研究的基础上进行扩展。它将在大规模腹腔镜研究中评价内部壳聚糖止血装置的有效性。申报的壳聚糖器械将提供安全、有效和方便的治疗，以控制腹腔镜手术期间的手术出血，并预防出血和尿漏相关的术后并发症。

项目成果

Use of a chitosan-based hemostatic dressing in laparoscopic partial nephrectomy.

基于壳聚糖的止血敷料在腹腔镜肾部分切除术中的应用。

• DOI: 10.1002/jbm.b.30946
• 发表时间: 2008
• 期刊: Journal of biomedical materials research. Part B, Applied biomaterials
• 作者: Xie,Hua;Khajanchee,YashodhanS;Teach,JeffreyS;Shaffer,BrianS
• 通讯作者: Shaffer,BrianS

Chitosan hemostatic dressing for renal parenchymal wound sealing in a porcine model: implications for laparoscopic partial nephrectomy technique.

壳聚糖止血敷料用于猪模型中肾实质伤口密封：对腹腔镜肾部分切除术技术的影响。

• 发表时间: 2008
• 期刊: JSLS : Journal of the Society of Laparoendoscopic Surgeons
• 作者: Xie,Hua;Khajanchee,YashodhanS;Shaffer,BrianS
• 通讯作者: Shaffer,BrianS