Chitosan hemostatic device for laparoscopic applications

描述（由申请人提供）： 术中出血可能是实质器官手术中的严重问题，并且在腹腔镜手术中通常难以管理。我们的长期目标是开发一种新型的内部壳聚糖止血装置，可以部署在腹腔镜下控制严重出血。基于壳聚糖的外部止血敷料已成功应用于控制各种创伤性损伤中的侵袭性出血。基于这些成功的研究，该提案的I期包括1）开发一种新型内部壳聚糖止血器械; 2）优化腹腔镜壳聚糖器械并开发其输送的腹腔镜技术; 3）评价肾部分切除术中的腹腔镜止血技术。第二阶段的建议，将扩大初步的第一阶段研究。它将在大规模腹腔镜研究中评价内部壳聚糖止血装置的有效性。申报的壳聚糖器械将提供安全、有效和方便的治疗，以控制腹腔镜手术期间的手术出血，并预防出血和尿漏相关的术后并发症。

DESCRIPTION (provided by applicant): Intraoperative bleeding can be a serious problem in parenchymal organ surgery and is generally difficult to manage during laparoscopic procedures. Our long-term goal is to develop a novel internal chitosan hemostatic device that can be deployed laparoscopically to control severe bleeding. External chitosan based hemostatic dressings have been applied successfully for control of aggressive hemorrhage in varying traumatic injuries. Based upon these successful studies, Phase I of this proposal includes 1) development of a novel internal chitosan hemostatic device; 2) optimization of the laparoscopic chitosan device and development of laparoscopic techniques for its delivery; and 3) evaluation of the laparoscopic hemostatic technique in partial nephrectomy. Phase II of the proposal, will expand upon the preliminary Phase I study. It will evaluate the efficacy of the internal chitosan hemostatic device in a large scale laparoscopic study. The proposed chitosan device(s) will provide safe, effective and convenient treatment to control surgical bleeding during the laparoscopic procedure and will prevent hemorrhage and urinary leakage related post-operative complications.