Chitosan hemostatic device for laparoscopic applications

描述(由申请人提供)： 术中出血在实质器官手术中可能是一个严重的问题，在腹腔镜手术中通常很难处理。我们的长期目标是开发一种新型的内部壳聚糖止血装置，该装置可以在腹腔镜下部署以控制严重出血。以壳聚糖为基础的外用止血敷料已成功地用于控制不同创伤中的侵袭性出血。在这些成功研究的基础上，该方案的第一阶段包括：1)开发一种新型的壳聚糖内止血装置；2)优化腹腔镜壳聚糖装置及其输送技术；3)评估腹腔镜止血技术在肾部分切除术中的应用。建议的第二阶段将在第一阶段初步研究的基础上扩展。它将在一项大规模的腹腔镜研究中评估壳聚糖内止血装置的效果。建议的壳聚糖装置(S)将提供安全、有效和方便的治疗方法，以控制腹腔镜术中的手术出血，并预防术后出血和尿漏相关的并发症。

DESCRIPTION (provided by applicant): Intraoperative bleeding can be a serious problem in parenchymal organ surgery and is generally difficult to manage during laparoscopic procedures. Our long-term goal is to develop a novel internal chitosan hemostatic device that can be deployed laparoscopically to control severe bleeding. External chitosan based hemostatic dressings have been applied successfully for control of aggressive hemorrhage in varying traumatic injuries. Based upon these successful studies, Phase I of this proposal includes 1) development of a novel internal chitosan hemostatic device; 2) optimization of the laparoscopic chitosan device and development of laparoscopic techniques for its delivery; and 3) evaluation of the laparoscopic hemostatic technique in partial nephrectomy. Phase II of the proposal, will expand upon the preliminary Phase I study. It will evaluate the efficacy of the internal chitosan hemostatic device in a large scale laparoscopic study. The proposed chitosan device(s) will provide safe, effective and convenient treatment to control surgical bleeding during the laparoscopic procedure and will prevent hemorrhage and urinary leakage related post-operative complications.