ANTI-HIV ACTIVITY OF P GINGIVALIS

牙龈卟啉单胞菌的抗HIV活性

• 批准号: 7380795
• 负责人: HUA XIE
• 金额: $ 35.09万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7380795
• 关键词: ANTI; HIV; ACTIVITY; GINGIVALIS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The human immunodeficiency virus (HIV) is transmitted to over 16,000 people each day worldwide. Our ongoing studies indicate P. gingivalis can inhibit HIV entry. The purpose of this study is to elucidate the mechanism by which the P. gingivalis component blocks the course of HIV infection. The specific effort of this proposal is to purify and characterize the inhibitory component of P. gingivalis, which may be capable of interfering with the oral transmission of HIV. Our initial investigation is aimed at determination of the prevalence and the anti-HIV activity of P. gingivalis strains isolated from periodontitis sites in HIV seropositive and HIV seronegative individuals, examination of correlation of viral loads and 17-kDa anti-HIV protein, and investigation of the effect of co-infection of HIV-1 and P. gingivalis on the pathogenicities of the organisms. The knowledge gained from this study is expected to increase our understanding of the rarity of HIV oral transmission and to provide new insights into the viral entry process. Furthermore, the study of the P. gingivalis inhibitory component might lead to the discovery of an additional target to complement current anti-HIV drugs.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。全世界每天有16 000多人感染人类免疫缺陷病毒（艾滋病毒）。我们正在进行的研究表明，牙龈卟啉菌可以抑制HIV的进入。本研究的目的是阐明牙龈假单胞菌成分阻断HIV感染过程的机制。本课题的具体工作是纯化和表征牙龈卟啉卟啉的抑制成分，该成分可能能够干扰HIV的口腔传播。我们的初步研究旨在确定从牙周炎部位分离的牙龈假单胞菌在HIV血清阳性和HIV血清阴性个体中的流行率和抗HIV活性，检查病毒载量和17-kDa抗HIV蛋白的相关性，以及研究HIV-1和牙龈假单胞菌共同感染对生物体致病性的影响。从这项研究中获得的知识有望增加我们对艾滋病毒口腔传播罕见性的理解，并为病毒进入过程提供新的见解。此外，对牙龈卟噬菌抑制成分的研究可能会导致发现一个额外的靶点来补充现有的抗hiv药物。