ANTI-HIV ACTIVITY OF P GINGIVALIS

牙龈卟啉单胞菌的抗HIV活性

• 批准号: 7622788
• 负责人: HUA XIE
• 金额: $ 22.37万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7622788
• 关键词: Complement; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; HIV; HIV-1; Individual; Infection; Institution; Investigation; Knowledge; Lead; Oral; Organism; Pathogenicity; Periodontitis; Pharmaceutical Preparations; Porphyromonas gingivalis; Prevalence; Process; Purpose; Research; Research Personnel; Resources; Site; Source; United States National Institutes of Health; Viral; Viral Load result; Viral Proteins; Virus Diseases; day; insight; transmission process

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The human immunodeficiency virus (HIV) is transmitted to over 16,000 people each day worldwide. Our ongoing studies indicate P. gingivalis can inhibit HIV entry. The purpose of this study is to elucidate the mechanism by which the P. gingivalis component blocks the course of HIV infection. The specific effort of this proposal is to purify and characterize the inhibitory component of P. gingivalis, which may be capable of interfering with the oral transmission of HIV. Our initial investigation is aimed at determination of the prevalence and the anti-HIV activity of P. gingivalis strains isolated from periodontitis sites in HIV seropositive and HIV seronegative individuals, examination of correlation of viral loads and 17-kDa anti-HIV protein, and investigation of the effect of co-infection of HIV-1 and P. gingivalis on the pathogenicities of the organisms. The knowledge gained from this study is expected to increase our understanding of the rarity of HIV oral transmission and to provide new insights into the viral entry process. Furthermore, the study of the P. gingivalis inhibitory component might lead to the discovery of an additional target to complement current anti-HIV drugs.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 人类免疫缺陷病毒(HIV)每天传播给全球超过16,000人。我们正在进行的研究表明，牙龈假单胞菌可以抑制艾滋病毒的进入。本研究的目的是阐明牙龈假单胞菌成分阻断HIV感染过程的机制。这项建议的具体工作是纯化和鉴定牙龈假单胞菌的抑制成分，该成分可能能够干扰HIV的口服传播。我们的初步调查旨在确定从HIV血清阳性和HIV血清阴性的牙周炎部位分离的Pggvalis菌株的流行率和抗HIV活性，检测病毒载量与17 kDa抗HIV蛋白的相关性，并探讨HIV-1和Pggivalis混合感染对微生物致病性的影响。从这项研究中获得的知识有望增加我们对艾滋病毒经口传播的罕见程度的了解，并为病毒进入过程提供新的见解。此外，对牙龈假单胞菌抑制成分的研究可能会导致发现一个补充现有抗HIV药物的额外靶点。