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Development of non-small cell lung cancer microarrays

Development of non-small cell lung cancer microarrays
非小细胞肺癌微阵列的开发
批准号：
6954042
负责人：
Jin Jen
金额：
$0.0万
依托单位：
DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6954042
关键词：
biomarker biotechnology cancer information system functional /structural genomics human subject immunocytochemistry microarray technology neoplasm /cancer diagnosis nonsmall cell lung cancer protein quantitation /detection technology /technique development

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英文摘要
We have constructed a lung tissue microarray containing 300 NSCLC samples and performed systematic examination of genes involved in several distinct biological pathways for their association with clinical outcome. We have so far identified at least four proteins, whose altered expression have prognostic value in NSCLC. We have also developed a lung cancer database that allows complex search included clinical pathological information, patient survival status, and protein expression based on immunohistochemistry analysis for over 50 gene products. We are continuing our effort to refine the database and to expand tissue array analysis to additional pathways and novel protein targets.
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Transcriptome map in non-small cell lung cancer
Gene expression profiles in lung cancer using cDNA array
Mechanisms of gene expression changes in lung cancer
Development of non-small cell lung cancer tissue microar
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