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Genetic/Behavior/Lifestyle Risk-Diabetes Mexican-America

遗传/行为/生活方式风险-糖尿病墨西哥-美国

基本信息

批准号：
7055542
负责人：
JOSEPH MCCORMICK
金额：
$ 49.6万
依托单位：
UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-07-15 至 2007-03-14
项目状态：
已结题

项目摘要

Type 2 diabetes mellitus poses major health burdens for individuals, families, and populations. Particular populations appear to be especially vulnerable to type 2 diabetes (T2DM). Among these is the Mexican American population that bears a disproportionate burden of T2DM. This has doubled in the last 2 decades, and is likely to increase further with rapid population growth and aging of this relatively young population, and earlier onset of T2DM. There will be increasingly costly and debilitating consequences of complications of Type 2 diabetes in larger numbers of patients, and earlier in life than we have seen hitherto. While susceptibility to type 2 diabetes mellitus has long been known to have a substantial genetic component, we hypothesize that there are also genetic components of the various complications. Risk factors for these implications will also encompass a range of behavioral and life style components which are at presently ill-defined. Our existing program examines not only the genetic component, but also life style and socioeconomic factors associated with T2DM in the Hispanic population in a small cohort. These studies are currently limited by an insufficiently large population of participants who can be followed both for the evolution of their diabetes, as well as the complications arising as disease progresses. In particular we wish to expand our understanding beyond some of the social and behavioral components of disease progress, and in particular assess the contribution of anxiety and depression, which is little studied in Mexican Americans. To this end, we propose to expand the existing funded and approved cohort study we have established among the Mexican American population in the Lower Rio Grande Valley. We now have access to the sophisticated genome scanning studies which have proceeded rapidly and the human gene expression map is maturing. Our strategy is therefore to exploit the interaction of genomics with behavioral, socioeconomic and lifestyle measures to provide the most robust measures of the components which predispose and lead to T2DM and its complications. The identification of precise risk factors for T2DM and ts complications in a Mexican American cultural/gene interaction setting will be the most productive way to move from general to individual approaches to prevention of both disease and its many complications.

2型糖尿病对个人、家庭和人群造成重大健康负担。特殊人群似乎特别容易患2型糖尿病（T2 DM）。其中，墨西哥裔美国人承担着不成比例的T2 DM负担。在过去的20年中，这一数字翻了一番，并且随着人口的快速增长和相对年轻人群的老龄化以及T2 DM的早期发病，这一数字可能会进一步增加。2型糖尿病的并发症将在更多的患者中产生越来越昂贵和衰弱的后果，并且比我们迄今为止所看到的更早。虽然2型糖尿病的易感性长期以来一直被认为具有大量的遗传成分，但我们假设各种并发症也有遗传成分。这些影响的风险因素还包括一系列目前定义不清的行为和生活方式组成部分。我们现有的项目不仅检查了遗传成分，还检查了一个小队列中西班牙裔人群中与T2 DM相关的生活方式和社会经济因素。这些研究目前受到参与者人数不足的限制，这些参与者可以跟踪糖尿病的演变以及随着疾病进展而出现的并发症。特别是，我们希望将我们的理解扩展到疾病进展的一些社会和行为组成部分之外，特别是评估焦虑和抑郁的影响，这在墨西哥裔美国人中研究得很少。为此，我们建议扩大现有的资助和批准的队列研究，我们已经建立了在下格兰德河流域的墨西哥裔美国人的人口。我们现在可以利用先进的基因组扫描研究，这些研究进展迅速，人类基因表达图正在成熟。因此，我们的策略是利用基因组学与行为，社会经济和生活方式措施的相互作用，以提供最强大的措施，易患和导致T2 DM及其并发症的组件。在墨西哥裔美国人文化/基因相互作用环境中识别T2 DM和TS并发症的精确风险因素将是从一般方法转向个体方法以预防疾病及其许多并发症的最有效方法。