2004 Gordon Research Conference on Chemotactic Cytokines

2004 年戈登趋化细胞因子研究会议

• 批准号: 6807332
• 负责人: Barrett J. Rollins
• 金额: $ 0.7万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6807332
• 关键词: chemotaxis; cytokine; meeting /conference /symposium; travel

DESCRIPTION (provided by applicant): Chemotactic cytokines, the largest subfamily of which are chemokines, play important roles in a variety of inflammatory diseases. For example, through the use of genetically modified mice or neutralizing antibodies, investigators have demonstrated the essential contribution of the chemokine system to atherosclerosis, multiple sclerosis (using EAE models), arthritis, inflammatory bowel disease, and several other disorders. More recently, chemokines and their receptors have been shown to participate directly in diseases in which inflammation may not play an inherently pathogenic role such as many cancers. This explosion of information has led to an active search for chemokine receptor antagonists. However, progress has been slow, and a variety of fundamental scientific issues have been uncovered that relate both to drug discovery and to the chemokine system itself. Meanwhile, exciting advances have occurred in the basic science of cell motility and movement-related signal transduction pathways. Thus a large community of investigators has evolved whose members are interested in chemotactic cytokines and who approach this interest from very diverse backgrounds. These scientists would benefit immensely from an opportunity to exchange ideas directly, and the Gordon Research Conference on Chemotactic Cytokines is designed to meet that need. This conference will meet in Aussois, France, in September 2004. It will be limited to 160 participants and will be international in flavor, although most attendees will be from the US. Conference speakers and topics have been chosen to reflect the newest cutting edge advances in the field. The conference is also intended to expose students, postdoctoral fellows, and other trainees to leading scientists. Support is requested to help cover the travel and registration costs at the European venue.

描述（由申请人提供）：趋化性细胞因子，其中最大的亚家族是趋化因子，在多种炎性疾病中发挥重要作用。 例如，通过使用转基因小鼠或中和抗体，研究人员已经证明了趋化因子系统对动脉粥样硬化、多发性硬化（使用EAE模型）、关节炎、炎症性肠病和其他几种疾病的重要贡献。 最近，趋化因子及其受体已被证明直接参与炎症可能不起固有致病作用的疾病，如许多癌症。 这种信息爆炸导致了对趋化因子受体拮抗剂的积极搜索。 然而，进展一直很缓慢，并且已经发现了与药物发现和趋化因子系统本身相关的各种基本科学问题。 与此同时，细胞运动和运动相关信号转导通路的基础科学也取得了令人兴奋的进展。 因此，一个庞大的社区的研究人员已经发展，其成员感兴趣的趋化细胞因子和谁接近这个兴趣从非常不同的背景。 这些科学家将从直接交流思想的机会中受益匪浅，戈登趋化性细胞因子研究会议旨在满足这一需求。 该会议将于2004年9月在法国奥苏瓦举行。它将被限制在160名参与者，将是国际风味，虽然大多数与会者将来自美国。 会议发言人和主题的选择反映了该领域的最新前沿进展。 会议还旨在让学生、博士后研究员和其他受训人员接触领先的科学家。 请求提供支助，以帮助支付在欧洲会场的旅费和登记费。