Investigating the role of TRP channels in the pathogenesis of multiple sclerosis

研究 TRP 通道在多发性硬化症发病机制中的作用

• 批准号: 2444359
• 金额: --
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2444359
• 关键词: Investigating; role; TRP; channels; pathogenesis

Research Question: Does oligodendrocyte TRPA1 channel regulate glial functioning and lead to less demyelination and increased remyelination in conditional TRPA1 -/-in oligodendrocytes compared to global TRPA1 -/-mice?Hypothesis:TRPA1 channels expressed on oligodendrocyte regulate glial functioning and become dysfunctional during demyelinating disease; TRPA1 -/-in oligodendrocytes is protective against demyelinationin the rodent cuprizone model. Aim 1:Validate the conditional TRPA1 -/-in oligodendrocyte compared to global TRPA1 -/-mice. Aim 2:Through use of the cuprizone model, determine the extent of demyelination in conditional TRPA1 -/-vs WTAim 3:Through use of the cuprizone model, determine the extent of remyelination in conditional TRPA1 -/-vs WT

研究问题：少突胶质细胞TRPA 1通道是否调节胶质细胞功能，并导致条件性TRPA 1-/-少突胶质细胞与整体TRPA 1-/-小鼠相比脱髓鞘减少和髓鞘再生增加？假设：在少突胶质细胞上表达的TRPA 1通道调节神经胶质功能，并在脱髓鞘疾病期间变得功能障碍;在啮齿动物铜腙模型中，少突胶质细胞中的TRPA 1-/-对脱髓鞘具有保护作用。目的1：与整体TRPA 1-/-小鼠相比，在少突胶质细胞中鉴定条件性TRPA 1-/-。目的2：通过使用cuprizone模型，确定条件性TRPA 1-/-vs WTAim的脱髓鞘程度3：通过使用cuprizone模型，确定条件性TRPA 1-/-vs WT的髓鞘再生程度

项目成果

Transient Receptor Potential Ankyrin-1 (TRPA1) Block Protects against Loss of White Matter Function during Ischaemia in the Mouse Optic Nerve.

• DOI: 10.3390/ph14090909
• 发表时间: 2021-09-09
• 期刊: Pharmaceuticals (Basel, Switzerland)
• 作者: Lajoso W;Flower G;Giacco V;Kaul A;La Mache C;Brăban A;Roxas A;Hamilton NB
• 通讯作者: Hamilton NB