TRP channel regulation of feeding behavior in Drosophila
TRP 通道对果蝇摄食行为的调节
基本信息
- 批准号:10683242
- 负责人:
- 金额:$ 48.3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-24 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:AcuteAdultAffectAgricultureAnimal BehaviorAnimalsBehaviorCalciumCircadian RhythmsCodeConsumptionCulicidaeDietDiseaseDisease VectorsDissectionDrosophila genusDrosophila melanogasterEatingEnergy IntakeEventFamilyFastingFeeding behaviorsFoodFood ProcessingGene ExpressionGenesGeneticHabitsHealthHomeostasisHumanHungerImageIngestionInsectaIntakeIntermittent fastingInterventionInvertebratesKnowledgeLifeLinkLogicMammalsMeasuresMechanical StimulationMediatingMemoryMetabolicMetabolismMethodsModelingMolecularMonitorNeurologicNeuronsNeuropeptidesNeurotransmittersNutrientNutritionalOrganismPainPainlessPatternPeptidesPesticidesPhenotypePhysiologicalPhysiologyPropertyProteinsPublishingRegulationRoleSatiationSensorySensory ReceptorsSeriesSignal TransductionSleepStomachStretchingSystemTRP channelTestingTimeage relateddesigndietaryfeedingflyfood consumptionhedonicimprovedinsightneuralneurogeneticsneuromechanismnutritionoptogeneticspharmacologicpreventreceptorresponseshear stresstemporal measurementtool
项目摘要
PROJECT SUMMARY: TRP channel regulation of feeding behavior in Drosophila
Feeding is one of the most fundamental of all animal behaviors. In mammals, diverse signals, including
chemosensory responses to food properties and mechanical stimulation of the gut, regulate satiation and
feeding behavior. These mechanisms, or analogous systems, are well-conserved in invertebrates. Although
many neuropeptides and neurotransmitters have been identified that signal satiation or satiety, much less is
known about how gut stretch and other mechanosensory forces are signaled to regulate feeding behavior.
Due to the remarkable conservation in their basic physiological and neurological properties, studies in
Drosophila have revolutionized our broad understanding of animal behavior. Despite the successful use of
flies in investigating paradigms such as sleep, circadian rhythm, and memory, only recently have tools for
measuring fly food intake facilitated the study of feeding behavior. This project will use Drosophila
melanogaster to investigate the regulation of meal intake. New methods allow undisturbed real-time
measurements of food consumption in freely behaving adult flies that resolve with unrivalled accuracy the
effects of diet and hunger on meal size. An experimental framework is established for defining fly meals and to
show their basic regulation by manipulation of the diet, internal hunger state, and circadian rhythms. Using the
powerful genetic tools available in Drosophila, preliminary results reveal the involvement of transient receptor
potential (TRP) channels in the regulation of meal intake. TRP channels define a large family of sensory
receptors, and much is still unknown about how they function as chemo-, mechano-, and other types of
receptors. The proposed studies will dissect the role of TRP channel signaling in satiation and meal size
control, taking advantage of the tools available in the simplified Drosophila model. Given the increasing
importance of meal intake and patterning on physiology and health—regardless of total caloric intake—the
proposed studies have the potential to reveal key insights on the role of TRP channel signaling on regulating
prandial behavior, physiology, and metabolism. The proposed studies may also eventually inform the design
of pesticides targeting TRP channels or feeding behavior in other insects, including agricultural pests and
disease vectors such as mosquitos.
果蝇摄食行为的TRP通道调控
进食是动物最基本的行为之一。在哺乳动物中,不同的信号,包括
对食物特性和肠道机械刺激的化学感受反应,调节饱足感,
摄食行为这些机制,或类似的系统,在无脊椎动物中是保守的。虽然
许多神经肽和神经递质已被鉴定为信号饱足或饱足感,
了解肠道拉伸和其他机械感觉力如何发出信号来调节进食行为。
由于其基本生理和神经特性的显著保守性,
果蝇彻底改变了我们对动物行为的广泛理解。尽管成功地使用了
苍蝇在研究范式,如睡眠,昼夜节律,和记忆,直到最近才有工具,
测量苍蝇的食物摄入量促进了进食行为的研究。这个项目将使用果蝇
黑腹果蝇,以研究膳食摄入的调节。新方法允许不受干扰的实时
测量自由行为的成年苍蝇的食物消耗,以无与伦比的准确性解决了
饮食和饥饿对膳食量的影响。建立了一个实验框架,用于定义苍蝇餐,
通过控制饮食、内部饥饿状态和昼夜节律来显示它们的基本调节。使用
果蝇中可用的强大遗传工具,初步结果揭示了瞬时受体的参与
潜在的(TRP)渠道在膳食摄入的调节。TRP通道定义了一个感觉神经元的大家族,
受体,并且关于它们如何作为化学,机械和其他类型的受体发挥作用仍然未知。
受体。这些研究将详细分析TRP通道信号在饱足和进食量中的作用
控制,利用简化果蝇模型中可用的工具。鉴于越来越
膳食摄入和饮食模式对生理和健康的重要性--无论总热量摄入如何--
提出的研究有可能揭示TRP通道信号转导在调节
饮食行为、生理学和新陈代谢。拟议的研究也可能最终为设计提供信息
针对TRP通道或其他昆虫(包括农业害虫)的摄食行为的农药,
病媒,如蚊子。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
WILLIAM W JA其他文献
WILLIAM W JA的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('WILLIAM W JA', 18)}}的其他基金
TRP channel regulation of feeding behavior in Drosophila
TRP 通道对果蝇摄食行为的调节
- 批准号:
10641098 - 财政年份:2021
- 资助金额:
$ 48.3万 - 项目类别:
TRP channel regulation of feeding behavior in Drosophila
TRP 通道对果蝇摄食行为的调节
- 批准号:
10494137 - 财政年份:2021
- 资助金额:
$ 48.3万 - 项目类别:
TRP channel regulation of feeding behavior in Drosophila
TRP 通道对果蝇摄食行为的调节
- 批准号:
10344523 - 财政年份:2021
- 资助金额:
$ 48.3万 - 项目类别:
Nutritional and Epigenetic Priming of Metabolism and Aging in Drosophila
果蝇代谢和衰老的营养和表观遗传启动
- 批准号:
8840866 - 财政年份:2014
- 资助金额:
$ 48.3万 - 项目类别:
Nutritional and Epigenetic Priming of Metabolism and Aging in Drosophila
果蝇代谢和衰老的营养和表观遗传启动
- 批准号:
8696160 - 财政年份:2014
- 资助金额:
$ 48.3万 - 项目类别:
Nutritional and Epigenetic Priming of Metabolism and Aging in Drosophila
果蝇代谢和衰老的营养和表观遗传启动
- 批准号:
9060847 - 财政年份:2014
- 资助金额:
$ 48.3万 - 项目类别:
Drosophila feeding behavior: New tools for the genetic dissection of prandiology
果蝇摄食行为:prandiology 基因剖析的新工具
- 批准号:
8318102 - 财政年份:2011
- 资助金额:
$ 48.3万 - 项目类别:
Drosophila feeding behavior: New tools for the genetic dissection of prandiology
果蝇摄食行为:prandiology 基因剖析的新工具
- 批准号:
8164958 - 财政年份:2011
- 资助金额:
$ 48.3万 - 项目类别:
Role of bacteria in development and lifespan of Drosophila melanogaster
细菌在果蝇发育和寿命中的作用
- 批准号:
8010996 - 财政年份:2010
- 资助金额:
$ 48.3万 - 项目类别:
Role of bacteria in development and lifespan of Drosophila melanogaster
细菌在果蝇发育和寿命中的作用
- 批准号:
8233401 - 财政年份:2010
- 资助金额:
$ 48.3万 - 项目类别:
相似海外基金
Co-designing a lifestyle, stop-vaping intervention for ex-smoking, adult vapers (CLOVER study)
为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
- 批准号:
MR/Z503605/1 - 财政年份:2024
- 资助金额:
$ 48.3万 - 项目类别:
Research Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
- 批准号:
2336167 - 财政年份:2024
- 资助金额:
$ 48.3万 - 项目类别:
Standard Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
- 批准号:
2402691 - 财政年份:2024
- 资助金额:
$ 48.3万 - 项目类别:
Standard Grant
Migrant Youth and the Sociolegal Construction of Child and Adult Categories
流动青年与儿童和成人类别的社会法律建构
- 批准号:
2341428 - 财政年份:2024
- 资助金额:
$ 48.3万 - 项目类别:
Standard Grant
Elucidation of Adult Newt Cells Regulating the ZRS enhancer during Limb Regeneration
阐明成体蝾螈细胞在肢体再生过程中调节 ZRS 增强子
- 批准号:
24K12150 - 财政年份:2024
- 资助金额:
$ 48.3万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Understanding how platelets mediate new neuron formation in the adult brain
了解血小板如何介导成人大脑中新神经元的形成
- 批准号:
DE240100561 - 财政年份:2024
- 资助金额:
$ 48.3万 - 项目类别:
Discovery Early Career Researcher Award
Laboratory testing and development of a new adult ankle splint
新型成人踝关节夹板的实验室测试和开发
- 批准号:
10065645 - 财政年份:2023
- 资助金额:
$ 48.3万 - 项目类别:
Collaborative R&D
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
- 批准号:
23K09542 - 财政年份:2023
- 资助金额:
$ 48.3万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Identification of new specific molecules associated with right ventricular dysfunction in adult patients with congenital heart disease
鉴定与成年先天性心脏病患者右心室功能障碍相关的新特异性分子
- 批准号:
23K07552 - 财政年份:2023
- 资助金额:
$ 48.3万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Issue identifications and model developments in transitional care for patients with adult congenital heart disease.
成人先天性心脏病患者过渡护理的问题识别和模型开发。
- 批准号:
23K07559 - 财政年份:2023
- 资助金额:
$ 48.3万 - 项目类别:
Grant-in-Aid for Scientific Research (C)