Mechanisms controlling liver development in zebrafish

描述(由申请人提供)： 了解肝脏发育的机制对于回答肝脏是如何获得其生理功能至关重要的。此外，了解控制胚胎和成人肝脏发育的分子事件，有望为旨在调节肝脏生长和再生的临床环境提供各种有用的治疗工具。这项建议旨在以斑马鱼为模型系统来了解控制肝脏发育的机制。

DESCRIPTION (provided by applicant): Understanding the mechanisms involved in liver development is essential for answering how the liver acquires its physiological function. In addition, understanding the molecular events controlling the development of the embryonic as well as adult liver has the promise of providing a variety of therapeutic tools useful in clinical settings aimed at regulating liver growth and regeneration. This proposal aims at understanding the mechanisms controlling liver development using zebrafish as a model system.